C
Cristiana Branco da Cunha
Researcher at Institute of Molecular Pathology and Immunology of the University of Porto
Publications - 9
Citations - 1141
Cristiana Branco da Cunha is an academic researcher from Institute of Molecular Pathology and Immunology of the University of Porto. The author has contributed to research in topics: Self-healing hydrogels & Alternative splicing. The author has an hindex of 5, co-authored 9 publications receiving 966 citations. Previous affiliations of Cristiana Branco da Cunha include Wyss Institute for Biologically Inspired Engineering & Leiden University.
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Journal ArticleDOI
Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
Ovijit Chaudhuri,Sandeep T. Koshy,Cristiana Branco da Cunha,Jae-Won Shin,Catia S. Verbeke,Kimberly H. Allison,David J. Mooney +6 more
TL;DR: It is demonstrated that interpenetrating networks of reconstituted basement membrane matrix and alginate can be used to modulate ECM stiffness independently of composition and architecture.
Journal ArticleDOI
Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology.
Cristiana Branco da Cunha,Darinka D. Klumpers,Darinka D. Klumpers,Darinka D. Klumpers,Weiwei Aileen Li,Weiwei Aileen Li,Sandeep T. Koshy,Sandeep T. Koshy,Sandeep T. Koshy,James C. Weaver,Ovijit Chaudhuri,Pedro L. Granja,Pedro L. Granja,David J. Mooney,David J. Mooney +14 more
TL;DR: Findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial deposited at the wound site could regulate the progression of wound healing.
Journal ArticleDOI
Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish.
Annemarie H. Meijer,Astrid M. van der Sar,Cristiana Branco da Cunha,Gerda E. M. Lamers,Mary Laplante,Hiroshi Kikuta,Wilbert Bitter,Thomas Becker,Herman P. Spaink +8 more
TL;DR: Using real-time confocal imaging, it is demonstrated that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma formation.
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De novo expression of CD44 variants in sporadic and hereditary gastric cancer
Cristiana Branco da Cunha,Carla Oliveira,Carla Oliveira,Xiaogang Wen,Bárbara Gomes,Sónia Sousa,Gianpaolo Suriano,Gianpaolo Suriano,Maritie Grellier,David G. Huntsman,Fátima Carneiro,Fátima Carneiro,Pedro L. Granja,Raquel Seruca,Raquel Seruca +14 more
TL;DR: The results raise the hypothesis of using CD44v6 as a marker of early invasive intramucosal carcinoma in HDGCCDH1 mutation carriers that lack CDH1 expression in their tumors.
Journal ArticleDOI
CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness.
Cristiana Branco da Cunha,Darinka D. Klumpers,Sandeep T. Koshy,James C. Weaver,Ovijit Chaudhuri,Raquel Seruca,Fátima Carneiro,Pedro L. Granja,David J. Mooney,David J. Mooney +9 more
TL;DR: 3D cultures revealed the same CD44 alternative splicing pattern previously observed in human premalignant and malignant gastric lesions, indicating that fundamental features of 3D cultures - such as soluble factors diffusion and mechanical cues - influence CD44 expression in GC cells.