Thomas Becker

TL;DR: The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.

TL;DR: It is shown that loss of bystander genes and other mutational events suffered by duplicated GRBs in teleost genomes permits target gene identification and HCNE/target gene assignment, which explains the absence of evolutionary breakpoints from large vertebrate chromosomal segments and will aid in the recognition of position effect mutations within human GRBs.

TL;DR: To facilitate the cloning of vertebrate genes that are important during embryogenesis, an insertional mutagenesis strategy in zebrafish using a retroviral vector is developed and three insertional mutants with embryonic lethal phenotypes are obtained.

TL;DR: Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES–ES and r-protein–ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

TL;DR: Evidence that microsynteny has been retained to keep large arrays of highly conserved noncoding elements (HCNEs) intact is presented and differences in core promoters between the target genes and the unrelated genes that offer an explanation for the differences in their responsiveness to enhancers are described.