Csilla Krausz

TL;DR: These EAU guidelines are a short comprehensive overview of the updated guidelines of male infertility as recently published by the EAU and are also available in the National Guideline Clearinghouse ( www.guideline.gov/).

TL;DR: The factors responsible for Y chromosome deletions in spermatozoa remain unresolved but may be one facet of a central reproductive problem: controlling the amount of oxidative stress experienced by germ cells during their differentiation and maturation in the male reproductive tract.

TL;DR: Large, international, and consortium-based whole-exome and whole-genome studies are the most promising approach for the discovery of the missing genetic aetiology of idiopathic male infertility.

TL;DR: The most recent revision of the 1999 laboratory guidelines summarizes the results of a 'Best Practice Meeting' held in Florence (Italy) in October 2003 as discussed by the authors, and it was agreed that the basic 1999 protocol, based on two multiplex polymerase chain reactions each covering the three AZF regions, is still fully valid and appropriate for accurate diagnosis.

TL;DR: The present revision of the 2004 laboratory guidelines summarizes all the clinical novelties related to the Y chromosome (classic, partial and gene‐specific deletions, genotype–phenotype correlations, methodological issues) and provides an update on the results of the quality control programme.