D
D. Gourdji
Researcher at French Institute of Health and Medical Research
Publications - 7
Citations - 598
D. Gourdji is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Somatostatin & Pituitary gland. The author has an hindex of 6, co-authored 7 publications receiving 570 citations.
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Journal ArticleDOI
Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.
Piotr Topilko,Sylvie Schneider-Maunoury,Giovanni Levi,Giovanni Levi,Alain Trembleau,D. Gourdji,MA Driancourt,Ch.V. Rao,Patrick Charnay +8 more
TL;DR: The data suggest that Krox-24 may have two distinct molecular functions in the anterior pituitary: transcriptional activation of the LHbeta gene in gonadotropes and control of cell proliferation and/or survival in somatotropes by unknown mechanisms.
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Hypothalamic and hypophyseal regulation of growth hormone secretion
TL;DR: Regulation and differentiation of somatotropes also depend upon paracrine processes within the pituitary itself and involve growth factors and several neuropeptides, for instance, vasoactive intestinal peptide, angiotensin 2, endothelin, and activin, as well as during inflammatory processes.
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Effect of 17β-Estradiol on Somatostatin Receptor Expression and Inhibitory Effects on Growth Hormone and Prolactin Release in Rat Pituitary Cell Cultures
Dragan Djordjijevic,Ji Zhang,M. Priam,Cécile Viollet,D. Gourdji,Claude Kordon,Jacques Epelbaum +6 more
TL;DR: Inhibition of cAMP accumulation by SRIF, OCT, and BIM-23052 was enhanced by exposure of cells to E2, and the rank of potency of the agonists was similar for GH and PRL inhibition.
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Chronic growth hormone (GH) hypersecretion induces reciprocal and reversible changes in mRNA levels from hypothalamic GH-releasing hormone and somatostatin neurons in the rat.
Jérôme Bertherat,José Timsit,Marie-Thérèse Bluet-Pajot,Jean-Jacques Mercadier,D. Gourdji,Claude Kordon,Jacques Epelbaum +6 more
TL;DR: Chronic GH hypersecretion affects the expression of the genes encoding for GHRH and SRIH, and the effect is long lasting, not desensitizable and reversible.
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Age-associated changes in hypothalamic and pituitary neuroendocrine gene expression in the rat.
TL;DR: Modifications in hypothalamic orexigenic and anorexigenic gene expression are in keeping with an age‐associated decrease in energy consumption but a higher one in the presence of macroprolactinomas.