P
Piotr Topilko
Researcher at École Normale Supérieure
Publications - 51
Citations - 5326
Piotr Topilko is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Schwann cell & Neural crest. The author has an hindex of 29, co-authored 49 publications receiving 4853 citations. Previous affiliations of Piotr Topilko include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Krox-20 controls myelination in the peripheral nervous system.
Piotr Topilko,Sylvie Schneider-Maunoury,Giovanni Levi,A. Baron-Van Evercooren,Amina Ben Younes Chennoufi,Tania Seitanidou,Charles Babinet,Patrick Charnay +7 more
TL;DR: It is demonstrated here that Krox-20 is also activated in Schwann cells before the onset of myelination and that its disruption blocks Schwann Cells at an early stage in their differentiation, thus preventing myelinations in the peripheral nervous system.
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Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
Igor Adameyko,Francois Lallemend,Jorge B. Aquino,Jorge B. Aquino,Jorge A. Pereira,Piotr Topilko,Thomas Müller,Nicolas Fritz,Anna Beljajeva,Makoto Mochii,Isabel Liste,Dmitry Usoskin,Ueli Suter,Carmen Birchmeier,Patrik Ernfors +14 more
TL;DR: Results reveal SCPs as a cellular origin of melanocytes, and have broad implications on the molecular mechanisms regulating skin pigmentation during development, in health and pigmentation disorders.
Journal ArticleDOI
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
Sylvie Schneider-Maunoury,Piotr Topilko,Tania Seitanidou,Giovanni Levi,Michel Cohen-Tannoudji,Sandrine Pournin,Charles Babinet,Patrick Charnay +7 more
TL;DR: It is concluded that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development.
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Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.
Piotr Topilko,Sylvie Schneider-Maunoury,Giovanni Levi,Giovanni Levi,Alain Trembleau,D. Gourdji,MA Driancourt,Ch.V. Rao,Patrick Charnay +8 more
TL;DR: The data suggest that Krox-24 may have two distinct molecular functions in the anterior pituitary: transcriptional activation of the LHbeta gene in gonadotropes and control of cell proliferation and/or survival in somatotropes by unknown mechanisms.
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Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons
TL;DR: The data suggest that the level of EphA4 protein in growing limb motor axons is involved in the selection of dorsal versus ventral trajectories, thus contributing to the topographic organisation of motor projections.