D
D. James Nokes
Researcher at Wellcome Trust
Publications - 161
Citations - 7976
D. James Nokes is an academic researcher from Wellcome Trust. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 35, co-authored 133 publications receiving 6220 citations. Previous affiliations of D. James Nokes include University of Warwick & Kenya Medical Research Institute.
Papers
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Journal ArticleDOI
Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine : a modelling study based on data from PCV10 introduction in Kilifi, Kenya
Stefan Flasche,John Ojal,John Ojal,Olivier le Polain de Waroux,Mark Otiende,Katherine L O'Brien,Moses C. Kiti,D. James Nokes,D. James Nokes,W. John Edmunds,J. Anthony G. Scott,J. Anthony G. Scott +11 more
TL;DR: It is found that catch-up campaigns are a highly dose-efficient way to accelerate population protection against pneumococcal disease.
Journal ArticleDOI
Airway response to respiratory syncytial virus has incidental antibacterial effects
Charles J. Sande,Charles J. Sande,James M. Njunge,Joyce M. Ngoi,Martin Mutunga,Timothy Chege,Elijah Gicheru,Elizabeth M. Gardiner,Agnes Gwela,Christopher A Green,Simon B. Drysdale,James A. Berkley,James A. Berkley,D. James Nokes,D. James Nokes,Andrew J. Pollard +15 more
TL;DR: Proteomics and metagenomics analyses of samples from Kenyan children report that RSV associates with Streptococcus burden and a local upper airway response with direct antibacterial properties, and appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children.
Journal ArticleDOI
Transmission patterns and evolution of respiratory syncytial virus in a community outbreak identified by genomic analysis.
Charles N. Agoti,Charles N. Agoti,Patrick K. Munywoki,Patrick K. Munywoki,My V. T. Phan,My V. T. Phan,James R. Otieno,Everlyn Kamau,Anne Bett,Ivy K. Kombe,George Githinji,Graham F. Medley,Patricia A. Cane,Paul Kellam,Paul Kellam,Matthew Cotten,Matthew Cotten,D. James Nokes,D. James Nokes +18 more
TL;DR: It is concluded that at the household level, most RSV infections arise from the introduction of a single virus variant followed by accumulation of household specific variation and analysis of complete virus genomes is crucial to better understand viral transmission in the community.
Journal ArticleDOI
The incidence and clinical burden of respiratory syncytial virus disease identified through hospital outpatient presentations in Kenyan children
TL;DR: The burden of childhood RSV-associated URTI and LRTI presenting to outpatients in this setting is considerable and the clinical features of cases associated with an RSV infection were more severe than cases without a RSV diagnosis.
Journal ArticleDOI
Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children
Susan C. Morpeth,Patrick K. Munywoki,Laura L. Hammitt,Laura L. Hammitt,Anne Bett,Christian Bottomley,Clayton Onyango,Clayton Onyango,David R. Murdoch,David R. Murdoch,D. James Nokes,D. James Nokes,J. Anthony G. Scott,J. Anthony G. Scott,J. Anthony G. Scott +14 more
TL;DR: It is observed that there is only a small increase in nasopharyngeal pneumococcal concentration during RSV or rhinovirus URTI, relative to natural variation, and other factors, such as host response to viral infection, may be more important than nasopharygeal pneumonia concentration in determining risk of invasive disease.