D
Dachun Yao
Researcher at Yeshiva University
Publications - 11
Citations - 2666
Dachun Yao is an academic researcher from Yeshiva University. The author has contributed to research in topics: Methylglyoxal & Diabetes mellitus. The author has an hindex of 9, co-authored 11 publications receiving 2423 citations. Previous affiliations of Dachun Yao include Stanford University & Albert Einstein College of Medicine.
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Journal ArticleDOI
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
Assam El-Osta,Daniella Brasacchio,Dachun Yao,Alessandro Pocai,Peter L. Jones,Robert G. Roeder,Mark E. Cooper,Mark E. Cooper,Michael Brownlee +8 more
TL;DR: It is shown that transient hyperglycemia induces long-lasting activating epigenetic changes in the promoter of the nuclear factor κB subunit p65 in aortic endothelial cells both in vitro and in nondiabetic mice, which cause increased p65 gene expression.
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Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands
Dachun Yao,Michael Brownlee +1 more
TL;DR: Results show that hyperglycemia-induced ROS production increases expression of RAGE and RAGE ligands, mediated by ROS-induced methylglyoxal, the major substrate of glyoxalase 1.
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The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
Hariharan Thangarajah,Dachun Yao,Edward I. Chang,Yubin Shi,Leila Jazayeri,Ivan N. Vial,Robert D. Galiano,Xue Liang Du,Raymon H. Grogan,Michael G. Galvez,Michael Januszyk,Michael Brownlee,Geoffrey C. Gurtner +12 more
TL;DR: Findings define molecular defects that underlie impaired VEGF production in diabetic tissues and offer a promising direction for therapeutic intervention.
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High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A
Dachun Yao,Tetsuya Taguchi,Takeshi Matsumura,Richard G. Pestell,Diane Edelstein,Ida Giardino,Guntram Suske,Naila Rabbani,Paul J. Thornalley,Vijay P. Sarthy,Hans-Peter Hammes,Michael Brownlee +11 more
TL;DR: In mouse kidney endothelial cells, high glucose causes increased methylglyoxal modification of the corepressor mSin3A, which results in increased recruitment of O-GlcNAc-transferase, with consequent increased modification of Sp3 by O-linked N-acetylglucosamine.
Journal ArticleDOI
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.
Daniel J. Ceradini,Dachun Yao,Raymon H. Grogan,Matthew J. Callaghan,Diane Edelstein,Michael Brownlee,Geoffrey C. Gurtner +6 more
TL;DR: Reactive oxygen species-induced modification of HIF1α by the glyoxalase 1 (GLO1) substrate methylglyoxal is hypothesized to cause impaired ischemia-induced vasculogenesis in patients with diabetes.