J
Jiachen Chu
Researcher at Johns Hopkins University School of Medicine
Publications - 9
Citations - 565
Jiachen Chu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 5 publications receiving 294 citations. Previous affiliations of Jiachen Chu include Harvard University & Zhejiang University.
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Journal ArticleDOI
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.
Jiefei Geng,Yasushi Ito,Linyu Shi,Palak Amin,Jiachen Chu,Amanda Tomie Ouchida,Adnan K. Mookhtiar,Heng Zhao,Daichao Xu,Bing Shan,Ayaz Najafov,Guangping Gao,Shizuo Akira,Junying Yuan,Junying Yuan +14 more
TL;DR: In this article, the authors show that TAK-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this critical decision.
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.
Chun Zhou,Xia Chen,Xia Chen,Rosa Planells-Cases,Jiachen Chu,Li Wang,Limin Cao,Zhihong Li,Karen I. López-Cayuqueo,Yadong Xie,Shiwei Ye,Xiang Wang,Florian Ullrich,Shixin Ma,Yiyuan Fang,Xiaoming Zhang,Zhikang Qian,Xiaozheng Liang,Shi Qing Cai,Zhengfan Jiang,Dongming Zhou,Qibin Leng,Tsan Sam Xiao,Ke Lan,Jinbo Yang,Huabin Li,Chao Peng,Zhaozhu Qiu,Thomas J. Jentsch,Hui Xiao +29 more
TL;DR: It is suggested that cell-to-cell transmission of cGAMP via LRRC8/VRAC channels is central to effective anti-viral immunity.
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Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke
TL;DR: During pathological cell swelling, deletion of astrocytic Swell1 attenuated glutamate-dependent neuronal excitability and protected mice from brain damage after ischemic stroke and provides a rationale for targeting VRAC for the treatment of stroke and other neurological diseases associated with excitotoxicity.
Journal ArticleDOI
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Junhua Yang,Jianan Chen,Maria del Carmen Vitery,James Osei-Owusu,Jiachen Chu,Haiyang Yu,Shuying Sun,Zhaozhu Qiu +7 more
TL;DR: The wide expression of PAC suggests a broad role for this conserved Cl− channel family in physiological and pathological processes associated with acidic pH, which is one of the hallmarks of many diseases including ischemia, cancer, and inflammation.
Journal ArticleDOI
A Novel Method to Image Macropinocytosis in Vivo.
Lunhao Chen,Daxiao Cheng,Jiachen Chu,Jiachen Chu,Ting Zhang,Zhuoer Dong,Huifang Lou,Liya Zhu,Yijun Liu +8 more
TL;DR: The microinjection of fluorescence dextrans together with or without ATPγS into transparent Drosophila melanogaster embryos provides a continent and reliable way for investigating macropinocytosis and its underlying mechanisms, especially when combined with genetic strategies.