D
Dan L. Longo
Researcher at Harvard University
Publications - 730
Citations - 59268
Dan L. Longo is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 125, co-authored 697 publications receiving 56085 citations. Previous affiliations of Dan L. Longo include University of Nebraska Omaha & Yale Cancer Center.
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Combination chemotherapy followed by an immunotoxin (anti-B4-blocked ricin) in patients with indolent lymphoma: results of a phase II study.
Dan L. Longo,P L Duffey,John G. Gribben,Elaine S. Jaffe,Brendan D. Curti,Barry L. Gause,John E. Janik,Virginia M. Braman,Dixie Lee Esseltine,Wyndham H. Wilson,Dwight Kaufman,Robert E. Wittes,Lee M. Nadler,W J Urba +13 more
TL;DR: ProMACE-CytaBOM plus anti-B4-blocked ricin does not produce durable complete remissions in the majority of patients with indolent lymphoma, however, the remissions appear quite durable (> 4 years) in about 40% of the complete responders.
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Macrophage Checkpoint Blockade in Cancer - Back to the Future.
Alberto Mantovani,Dan L. Longo +1 more
TL;DR: Macrophages are an essential component of the tumor microenvironment and have been ascribed a role in cancer-promoting inflammation.
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A Phase I Trial of B7-Transfected or Parental Lethally Irradiated Allogeneic Melanoma Cell Lines to Induce Cell-Mediated Immunity Against Tumor-Associated Antigen Presented by HLA-A2 or HLA-A1 in Patients with Stage IV Melanoma. National Institutes of Health, Bethesda, Maryland
TL;DR: A phase I trial of B7-transfected allogeneic melanoma cell lines to induce cell-mediated immunity against tumor-associated antigens presented by HLA-A2 or Hla-A1 in patients with stage IV melanoma.
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Hck expression correlates with granulocyte-macrophage colony- stimulating factor-induced proliferation in HL-60 cells
TL;DR: Results show that cytokine receptors can exist in an uncoupled form and suggest that in HL-60 cells, appropriate levels of the src-like tyrosine kinase hck are critical for functional coupling of the GM-CSFR to biologic responses.
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The Antineoplastic Agent Bryostatin-1 Induces Proinflammatory Cytokine Production in Human Monocytes: Synergy With Interleukin-2 and Modulation of Interleukin-2Rγ Chain Expression
Maria Carla Bosco,Sandra Rottschafer,Lynn S. Taylor,John R. Ortaldo,Dan L. Longo,Igor Espinoza-Delgado +5 more
TL;DR: It is demonstrated that bryo-1 can potently induce the production of pro-inflammatory cytokines from human peripheral blood monocytes and suggests that stimulation of monokine secretion by bryO-1 may represent at least one of the mechanisms responsible for the in vivo antitumor activity of this drug.