D
Dan L. Longo
Researcher at Harvard University
Publications - 730
Citations - 59268
Dan L. Longo is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 125, co-authored 697 publications receiving 56085 citations. Previous affiliations of Dan L. Longo include University of Nebraska Omaha & Yale Cancer Center.
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A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
Silvia Naitza,Eleonora Porcu,Maristella Steri,Dennis D. Taub,Antonella Mulas,Xiang Xiao,James B. Strait,Mariano Dei,Sandra Lai,Fabio Busonero,Andrea Maschio,Gianluca Usala,Magdalena Zoledziewska,Carlo Sidore,Carlo Sidore,Carlo Sidore,Ilenia Zara,Maristella Pitzalis,Alessia Loi,Francesca Virdis,Roberta Piras,Francesca Deidda,Michael B. Whalen,Laura Crisponi,Antonio Concas,Carlo Podda,Sergio Uzzau,Paul Scheet,Dan L. Longo,Edward G. Lakatta,Gonçalo R. Abecasis,Antonio Cao,David Schlessinger,Manuela Uda,Serena Sanna,Francesco Cucca,Francesco Cucca +36 more
TL;DR: The results improve the current knowledge of genetic variants underlying inflammation and provide novel clues for the understanding of the molecular mechanisms regulating this complex process.
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T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells.
Dan L. Longo,Ronald H. Schwartz +1 more
TL;DR: Examining the turnover of APCs in the thymuses of F1→parent (P) radiation-induced bone marrow chimaeras found that APCs of donor phenotype appear at about 2 months after reconstitution, suggesting that cells from the bone marrow can influence thymic-directed T-cell differentiation.
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Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes
Juan B. Ochoa,Brendan D. Curti,Andrew B. Peitzman,Richard L. Simmons,Timothy R. Billiar,Rosemary A. Hoffman,Raymond Rault,Dan L. Longo,W J Urba,Augusto C. Ochoa +9 more
TL;DR: It is proposed that mediated induction of .N = O synthase enzyme leads to progressive increases in .N + O production which produces clinically significant hypotension, which could contribute to better management of toxic side effects seen in IL-2 cancer therapies.
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The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.
Daniel L. Chase,Christina Serafinas,Neville R. Ashcroft,Mary E. Kosinski,Dan L. Longo,Douglas K. Ferris,Andy Golden +6 more
TL;DR: The Polo‐like kinases are key regulatory molecules required during the cell cycle for the successful completion of mitosis and disruption of PLK‐1 expression by RNA‐mediated interference (RNAi) disrupts normal oocyte and embryonic development.
Journal Article
Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity.
TL;DR: The ability of bryostatin 1 to inhibit the in vitro growth and in vivo development of a panel of four murine tumors of diverse tissue origins and the observation that five of a Panel of six human B-cell lymphoma cell lines were sensitive to the growth inhibitory effects of bRYostatin in vitro suggest that brystatin may be effective in treating lymphoid malignancies in humans.