D
Dan L. Longo
Researcher at Harvard University
Publications - 730
Citations - 59268
Dan L. Longo is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 125, co-authored 697 publications receiving 56085 citations. Previous affiliations of Dan L. Longo include University of Nebraska Omaha & Yale Cancer Center.
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Journal ArticleDOI
Treatment of advanced non-Hodgkin's lymphoma with recombinant leukocyte A interferon.
Kenneth A. Foon,Stephen A. Sherwin,Paul G. Abrams,Dan L. Longo,Mehmet F. Fer,Henry C. Stevenson,Jeffrey J. Ochs,Gino C. Bottino,Carolyn S. Schoenberger,Jacob Zeffren,Elaine S. Jaffe,Robert K. Oldham +11 more
TL;DR: It is suggested that recombinant leukocyte A interferon may be an effective new therapy for some patients with low- and intermediate-grade non-Hodgkin's lymphoma.
Journal ArticleDOI
Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase.
Mark R. Smith,Michael L. Wilson,Ryoji Hamanaka,Daniel L. Chase,Hsiang-Fu Kung,Dan L. Longo,Douglas K. Ferris +6 more
TL;DR: It is reported that microinjection of Plk mRNA is sufficient to drive quiescent cells into mitosis and that constitutive expression of PlK in NIH 3T3 cells causes oncogenic focus formation.
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Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor.
Larry W. Kwak,P L Duffey,Craig W. Reynolds,Dan L. Longo,Dennis D. Taub,W.I. Bensinger,E.M. Bryant +6 more
TL;DR: Testing the hypothesis that tumour antigen-specific immunity can be transferred from bone-marrow-transplant donor to recipient proved that a myeloma idiotype-specific T-cell response was successfully transferred to the recipient.
Journal ArticleDOI
T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo.
TL;DR: Results demonstrate that neutrophils store and release, upon stimulation with IL-8 or other neutrophil activators, chemoattractants that mediate T cell and monocyte accumulation at sites of inflammation.
Journal ArticleDOI
Inhibition of Human B-Cell Lymphoma Growth by CD40 Stimulation
Satoshi Funakoshi,Dan L. Longo,Margaret Beckwith,Denise K. Conley,Galia Tsarfaty,IIan Tsarfaty,Richard J. Armitage,William C. Fanslow,Melanie K. Spriggs,William J. Murphy +9 more
TL;DR: When various human B-cell lymphomas were transferred into mice with severe combined immune deficiency, the treatment of the mice with anti- CD40 antibodies resulted in significant increases in survival showing that anti-CD40 is efficacious after in vivo administration.