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Dana T. Minnick
Researcher at Research Triangle Park
Publications - 9
Citations - 1635
Dana T. Minnick is an academic researcher from Research Triangle Park. The author has contributed to research in topics: DNA polymerase & Klenow fragment. The author has an hindex of 9, co-authored 9 publications receiving 1577 citations. Previous affiliations of Dana T. Minnick include National Institutes of Health.
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Journal ArticleDOI
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
Celia P. Briscoe,Mohammad Tadayyon,E. John L. Andrews,William G. Benson,Jon K. Chambers,Michelle M. Eilert,Catherine E. Ellis,Nabil Elshourbagy,Aaron S. Goetz,Dana T. Minnick,Paul R. Murdock,Howard Ray Sauls,Usman Shabon,Lisa D. Spinage,Jay C. Strum,Philip G. Szekeres,Kong B. Tan,James M. Way,Diane M. Ignar,Shelagh Wilson,Alison I. Muir +20 more
TL;DR: expression analysis by quantitative reverse transcription-PCR showed that GPR40 was specifically expressed in brain and Pancreas, with expression in rodent pancreas being localized to insulin-producing β-cells.
Journal ArticleDOI
Side Chains That Influence Fidelity at the Polymerase Active Site of Escherichia coli DNA Polymerase I (Klenow Fragment)
Dana T. Minnick,Katarzyna Bebenek,Wendy P. Osheroff,Robert M. Turner,Mekbib Astatke,Lixing Liu,Thomas A. Kunkel,Catherine M. Joyce +7 more
TL;DR: Analysis of base substitution errors at four template positions indicated that each of the five mutator polymerases has its own characteristic error specificity, suggesting that the Arg-668, Arg-682, Glu-710, Tyr-766, and Asn-845 side chains may contribute to polymerase fidelity in a variety of different ways.
Journal ArticleDOI
DNA replication fidelity with 8-oxodeoxyguanosine triphosphate
TL;DR: Analysis of sequence analysis of mutants suggests that 8-O-dGMP is misincorporated opposite template adenines, yielding A-->C transversions, and a direct comparison of the fidelity of proofreading-proficient andProofreading-deficient Klenow and T4 DNA polymerases suggests that the A.8-O+GMP mispair can be proofread.
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Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.
TL;DR: The in vivo inhibitory effects observed with metformin and pioglitazone on serum D PP-IV activity results from reduced DPP-IV secretion.
Journal ArticleDOI
A Thumb Subdomain Mutant of the Large Fragment of Escherichia coli DNA Polymerase I with Reduced DNA Binding Affinity, Processivity, and Frameshift Fidelity
TL;DR: Observations suggest a role for the tip of the thumb of Klenow polymerase in determining DNA binding, processivity and frameshift fidelity, perhaps by tracking the minor groove of the duplex DNA.