M
Mark Yarchoan
Researcher at Johns Hopkins University
Publications - 130
Citations - 8085
Mark Yarchoan is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 29, co-authored 90 publications receiving 4901 citations. Previous affiliations of Mark Yarchoan include Johns Hopkins University School of Medicine & Stanford University.
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Journal ArticleDOI
Tumor Mutational Burden and Response Rate to PD-1 Inhibition
TL;DR: In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1.
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Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
Timothy A. Chan,Mark Yarchoan,Elizabeth M. Jaffee,Charles Swanton,Sergio A. Quezada,Albrecht Stenzinger,Solange Peters +6 more
TL;DR: TMB, in concert with PD-L1 expression, has been demonstrated to be a useful biomarker for ICB selection across some cancer types; however, further prospective validation studies are required.
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Targeting neoantigens to augment antitumour immunity
TL;DR: This Review discusses the emerging evidence that neoantigens are recognized by the immune system and can be targeted to increase antitumour immunity, and provides a framework for personalized cancer immunotherapy through the identification and selective targeting of individual tumour neoantIGens.
Journal ArticleDOI
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.
Mark Yarchoan,Lee A. Albacker,Alexander Hopkins,Meagan Montesion,Karthikeyan Murugesan,Teena Vithayathil,Neeha Zaidi,Nilofer S. Azad,Daniel A. Laheru,Garrett M. Frampton,Elizabeth M. Jaffee +10 more
TL;DR: The results indicate that PD-L1 expression and TMB may each inform the use of ICIs, point to different mechanisms by which PD- L1 expression regulates ICI responsiveness, and identify new opportunities for therapeutic development.
Journal ArticleDOI
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
Mark Yarchoan,Sharon X. Xie,Mitchel A. Kling,Mitchel A. Kling,Jon B. Toledo,David A. Wolk,Edward B. Lee,Vivianna M. Van Deerlin,Virginia M.-Y. Lee,John Q. Trojanowski,Steven E. Arnold +10 more
TL;DR: The results provide further confirmation and specificity that vascular disease and Alzheimer's disease are interrelated and suggest that common aetiologic or reciprocally synergistic pathophysiological mechanisms promote both vascular pathology and plaque and tangle pathology.