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Daniel A. Patten
Researcher at University of Birmingham
Publications - 28
Citations - 876
Daniel A. Patten is an academic researcher from University of Birmingham. The author has contributed to research in topics: Proinflammatory cytokine & Chronic liver disease. The author has an hindex of 13, co-authored 25 publications receiving 612 citations. Previous affiliations of Daniel A. Patten include National Institute for Health Research & University of Huddersfield.
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Journal ArticleDOI
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare,Yoko Ito,Tae-Won Kang,Michael P. Weekes,Nicholas J Matheson,Daniel A. Patten,Shishir Shetty,Aled Parry,Suraj Menon,Rafik Salama,Robin Antrobus,Kosuke Tomimatsu,William J. Howat,Paul J. Lehner,Lars Zender,Masashi Narita +15 more
TL;DR: It is shown that the dynamic alteration of NOTCH1 activity during senescence dictates a functional balance between these two distinct secretomes: one representing TGF-β and the other pro-inflammatory cytokines, highlighting that NotCH1 is a temporospatial controller of secretome composition.
Journal ArticleDOI
Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury
Pia Rantakari,Daniel A. Patten,Joona Valtonen,Marika Karikoski,Heidi Gerke,Helen Dawes,Juha P. Laurila,Steffen Ohlmeier,Kati Elima,Stefan G. Hübscher,Christopher J. Weston,Sirpa Jalkanen,David H. Adams,Marko Salmi,Shishir Shetty +14 more
TL;DR: A previously unidentified regulatory pathway in fibrogenesis in which a macrophage scavenger receptor protects against organ fibrosis by removing fibrogenic products of lipid peroxidation is demonstrated.
Journal ArticleDOI
Lactobacillus-produced exopolysaccharides and their potential health benefits: a review
Daniel A. Patten,Andrew P. Laws +1 more
TL;DR: In this paper, a review of the production of exopolysaccharides within the Lactobacillus genus and explore their potential as beneficial bioactive compounds is presented. But the authors do not discuss the potential of these compounds to be used as probiotic enhancers in fermented foods.
Lactobacillus-produced exopolysaccharides and their potential health benefits:
TL;DR: In this review, the production of exopolysaccharides within the Lactobacillus genus are discussed and their potential as beneficial bioactive compounds are explored.
Journal ArticleDOI
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.
Abhishek Chauhan,Lozan Sheriff,Mohammed T. Hussain,Gwilym J. Webb,Daniel A. Patten,Emma L. Shepherd,Robert K. Shaw,Christopher J. Weston,Debashis Haldar,Samuel Bourke,Rajan Bhandari,Stephanie Watson,David H. Adams,Steve P. Watson,Steve P. Watson,Patricia F. Lalor +15 more
TL;DR: It is demonstrated that blocking platelet CLEC-2 signalling enhances liver recovery from acute toxic liver injuries by increasing tumour necrosis factor-α (TNF-α) production which then enhances reparative hepatic neutrophil recruitment.