A
Aled Parry
Researcher at Babraham Institute
Publications - 19
Citations - 1400
Aled Parry is an academic researcher from Babraham Institute. The author has contributed to research in topics: Chromatin & Epigenetics. The author has an hindex of 10, co-authored 16 publications receiving 886 citations. Previous affiliations of Aled Parry include University of Bath & Garvan Institute of Medical Research.
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Journal ArticleDOI
G-quadruplex structures mark human regulatory chromatin
Robert Hänsel-Hertsch,Dario Beraldi,Stefanie V Lensing,Giovanni Marsico,Katherine G. Zyner,Aled Parry,Marco Di Antonio,Jeremy A. Pike,Hiroshi Kimura,Masashi Narita,David Tannahill,Shankar Balasubramanian +11 more
TL;DR: The development of G4 ChIP–seq, an antibody-based G4 chromatin immunoprecipitation and high-throughput sequencing approach, shows that regulatory, nucleosome-depleted chromatin and elevated transcription shape the endogenous human G4 DNA landscape.
Journal ArticleDOI
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare,Yoko Ito,Tae-Won Kang,Michael P. Weekes,Nicholas J Matheson,Daniel A. Patten,Shishir Shetty,Aled Parry,Suraj Menon,Rafik Salama,Robin Antrobus,Kosuke Tomimatsu,William J. Howat,Paul J. Lehner,Lars Zender,Masashi Narita +15 more
TL;DR: It is shown that the dynamic alteration of NOTCH1 activity during senescence dictates a functional balance between these two distinct secretomes: one representing TGF-β and the other pro-inflammatory cytokines, highlighting that NotCH1 is a temporospatial controller of secretome composition.
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Active turnover of DNA methylation during cell fate decisions.
TL;DR: This work discusses the phenomenon of concomitant activity of de novo methylation and demethylation machineries, and proposes that DNA methylation turnover may facilitate key lineage decisions.
Journal ArticleDOI
IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype
Kimberley A. Wiggins,Aled Parry,Liam D. Cassidy,Melanie Humphry,Steve J. Webster,Jane C. Goodall,Masashi Narita,Murray C.H. Clarke +7 more
TL;DR: In this paper, the authors identify IL-1α as a novel substrate of noncanonical inflammatory caspases and finally provide a mechanism for how IL1α is activated during senescence.
Journal ArticleDOI
Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains.
Amanda Khoury,Joanna Achinger-Kawecka,Saul A. Bert,Grady C. Smith,Hugh J. French,Phuc-Loi Luu,Tim J Peters,Qian Du,Aled Parry,Fatima Valdes-Mora,Phillippa C. Taberlay,Phillippa C. Taberlay,Clare Stirzaker,Clare Stirzaker,Aaron L. Statham,Susan J. Clark,Susan J. Clark +16 more
TL;DR: It is found that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain boundaries and chromatin loops constitutive to all cell types.