D
Daniel Fourmy
Researcher at University of Toulouse
Publications - 103
Citations - 2369
Daniel Fourmy is an academic researcher from University of Toulouse. The author has contributed to research in topics: Receptor & Cholecystokinin. The author has an hindex of 30, co-authored 101 publications receiving 2180 citations. Previous affiliations of Daniel Fourmy include Paul Sabatier University & French Institute of Health and Medical Research.
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Targeting a G-protein-coupled receptor overexpressed in endocrine tumors by magnetic nanoparticles to induce cell death.
Claire Sanchez,Darine El Hajj Diab,Vincent Connord,Pascal Clerc,Etienne Meunier,Bernard Pipy,Bruno Payré,Reasmey P. Tan,Michel Gougeon,Julian Carrey,Véronique Gigoux,Daniel Fourmy +11 more
TL;DR: A nanoplatform composed of an iron oxide nanocrystal decorated with a ligand of a G-protein coupled receptor, the cholecystokinin-2 receptor that is overexpressed in several malignant cancers is designed, demonstrating that cell death is triggered even though nanoparticles of low thermal power are internalized in minute amounts by the cells.
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Targeted Magnetic Intra-Lysosomal Hyperthermia produces lysosomal reactive oxygen species and causes Caspase-1 dependent cell death.
Pascal Clerc,Pauline Jeanjean,N. Hallali,Michel Gougeon,Bernard Pipy,Julian Carrey,Daniel Fourmy,Véronique Gigoux +7 more
TL;DR: Using Gastrin‐grafted MNPs specifically delivered to lysosomes of tumor cells from different cancers, evidence is provided that MILH causes cell death through a non‐apoptotic signaling pathway and highlights the clear potential of MILH for the eradication of tumors overexpressing receptors.
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Biologically active recombinant human progastrin(6-80) contains a tightly bound calcium ion.
Graham S. Baldwin,Frédéric Hollande,Zhiyu Yang,Yulia Karelina,Adrienne C. Paterson,Rosslyn Strang,Rosslyn Strang,Daniel Fourmy,Greg Neumann,A Shulkes +9 more
TL;DR: It is concluded that recombinant human progastrin6–80 is biologically active and contains a single calcium ion, the first report of selective, high affinity binding of metal ions to a prohormone.
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Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice.
Pascal Clerc,Maria Gràcia Coll Constans,Hubert Lulka,Hubert Lulka,Stéphanie Broussaud,Charlotte Guigné,Stéphane Leung-Theung-Long,Christophe Perrin,Claude Knauf,Christian Carpéné,Luc Pénicaud,Catherine Seva,Rémy Burcelin,Philippe Valet,Daniel Fourmy,Marlène Dufresne +15 more
TL;DR: Evidence is given that CCK2 receptor activity plays a contributing regulatory role in the control of food intake as revealed by increased fasting glycemia and insulinemia, impaired glucose tolerance, and hepatic insulin resistance inCCK2R(-/-) mice.
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Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand
Tahir Yaqub,Irina G. Tikhonova,Jens Lättig,Remi Magnan,Marie Laval,Chantal Escrieut,Cyril Boulègue,Chandralal M. Hewage,Daniel Fourmy +8 more
TL;DR: Identification of residues in the GIPR involved in functional interaction with N-terminal moiety of GIP represents an important step toward understanding activation of G IPR by GIP, which should facilitate the rational design of therapeutic agents.