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Daniel G. Bracewell
Researcher at University College London
Publications - 144
Citations - 3909
Daniel G. Bracewell is an academic researcher from University College London. The author has contributed to research in topics: Bioprocess & Packed bed. The author has an hindex of 31, co-authored 134 publications receiving 3194 citations. Previous affiliations of Daniel G. Bracewell include University of Kent.
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Journal ArticleDOI
Manufacturing Exosomes:A Promising Therapeutic Platform
TL;DR: It is hypothesize that transitioning to defined manufacturing platforms will increase consistency of the exosome product and improve their clinical advancement as a new therapeutic tool.
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Soft sensors in bioprocessing: A status report and recommendations
Reiner Luttmann,Daniel G. Bracewell,Gesine Cornelissen,Krist V. Gernaey,Jarka Glassey,Volker C. Hass,Christian M. Kaiser,Christian Preusse,Gerald Striedner,Carl-Fredrik Mandenius +9 more
TL;DR: The panel was to provide an update on the present status of the subject and to identify critical needs and issues for the furthering of the successful development of soft sensor methods in bioprocess engineering research and for industrial applications, in particular with focus on biopharmaceutical applications.
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Advances in product release strategies and impact on bioprocess design.
TL;DR: The selective release of products is reviewed and discussed as a possible means of improving the efficiency of downstream processing.
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The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.
TL;DR: A nascent approach to risk assessment of HCPs based upon such data is described, drawing attention to timeliness in relation to biosimilar initiatives.
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Host cell protein dynamics in the supernatant of a mAb producing CHO cell line.
TL;DR: The data suggests that the majority of HCPs in the supernatant of the cell lines investigated here arise through lysis or breakage of cells, associated with loss in viability, and are not present due to the secretion of protein material from within the cell.