D
Daniel M. Kemp
Researcher at Novartis
Publications - 36
Citations - 2148
Daniel M. Kemp is an academic researcher from Novartis. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 19, co-authored 36 publications receiving 1971 citations. Previous affiliations of Daniel M. Kemp include Emerald Group Publishing & University of Kent.
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Journal ArticleDOI
Minireview: Transcriptional Regulation in Pancreatic Development
TL;DR: An understanding of the importance of transcription factor genes during pancreas development has provided insights into the pathogenesis of diabetes, in which the mass of insulin-producing beta-cells is reduced.
Journal ArticleDOI
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Robert W. Myers,Hong-Ping Guan,Juliann Ehrhart,Aleksandr Petrov,Srinivasa Prahalada,Effie Tozzo,Xiaodong Yang,Marc M. Kurtz,Maria E. Trujillo,Dinko Gonzalez Trotter,Danqing Feng,Shiyao Xu,George J. Eiermann,Marie A. Holahan,Daniel Rubins,Stacey Conarello,Xiaoda Niu,Sandra C. Souza,Corin O. Miller,Jinqi Liu,Ku Lu,Wen Feng,Ying Li,Ronald E. Painter,James A. Milligan,Huaibing He,Franklin Liu,Aimie Ogawa,Douglas Wisniewski,Rory J. Rohm,Liyang Wang,Michelle Bunzel,Ying Qian,Wei Zhu,Hongwu Wang,Bindu Bennet,Lisa LaFranco Scheuch,Guillermo Fernandez,Cai Li,Michael Klimas,Gaochao Zhou,Margaret van Heek,Tesfaye Biftu,Ann E. Weber,David E. Kelley,Nancy A. Thornberry,Mark D. Erion,Daniel M. Kemp,Iyassu K. Sebhat +48 more
TL;DR: MK-8722 is developed, a potent, direct, allosteric activator of all 12 mammalian AMPK complexes that induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia in rodents and rhesus monkeys.
Journal ArticleDOI
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort
Danielle M. Greenawalt,Radu Dobrin,Eugene Chudin,Ida J. Hatoum,Christine Suver,John Beaulaurier,Bin Zhang,Victor M. Castro,Jun Zhu,Solveig K. Sieberts,Susanna Wang,Cliona Molony,Steven B. Heymsfield,Daniel M. Kemp,Marc L. Reitman,Pek Yee Lum,Eric E. Schadt,Lee M. Kaplan +17 more
TL;DR: It is demonstrated how these eSNPs provide a high-quality disease map for each tissue in morbidly obese patients to not only inform genetic associations identified in this cohort, but in previously published genome-wide association studies as well.
Journal ArticleDOI
Human adipose-derived stem cells display myogenic potential and perturbed function in hypoxic conditions.
Jee-Hyung Lee,Daniel M. Kemp +1 more
TL;DR: The relative accessibility of adipose-derived mesenchymal stem cells from human donors provides opportunity for molecular investigation of mechanistic dysfunction in disease settings and may introduce new prospects for cell-based therapy.
Journal ArticleDOI
Common body mass index-associated variants confer risk of extreme obesity
Chris Cotsapas,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Ida J. Hatoum,Ida J. Hatoum,Danielle M. Greenawalt,Radu Dobrin,Pek Yee Lum,Christine Suver,Eugene Chudin,Daniel M. Kemp,Marc L. Reitman,Benjamin F. Voight,Benjamin M. Neale,Eric E. Schadt,Joel N. Hirschhorn,Joel N. Hirschhorn,Lee M. Kaplan,Lee M. Kaplan,Mark J. Daly +19 more
TL;DR: It is suggested that variants influencing BMI also contribute to severe obesity, a condition at the extreme of the phenotypic spectrum rather than a distinct condition.