C
Cliona Molony
Researcher at Merck & Co.
Publications - 42
Citations - 8794
Cliona Molony is an academic researcher from Merck & Co.. The author has contributed to research in topics: Genome-wide association study & Candidate gene. The author has an hindex of 26, co-authored 40 publications receiving 8051 citations. Previous affiliations of Cliona Molony include United States Military Academy & University of Pennsylvania.
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Journal ArticleDOI
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang,Chris Gaiteri,Liviu-Gabriel Bodea,Zhi Wang,Joshua J McElwee,Alexei A. Podtelezhnikov,Chunsheng Zhang,Tao Xie,Linh M. Tran,Radu Dobrin,Eugene M. Fluder,Bruce E. Clurman,Stacey Melquist,Manikandan Narayanan,Christine Suver,Hardik Shah,Milind Mahajan,Tammy Gillis,Jayalakshmi S. Mysore,Marcy E. MacDonald,John Lamb,David A. Bennett,Cliona Molony,David J. Stone,Vilmundur Gudnason,Amanda J. Myers,Eric E. Schadt,Harald Neumann,Jun Zhu,Valur Emilsson +29 more
TL;DR: The causal network structure is a useful predictor of response to gene perturbations and presents a framework to test models of disease mechanisms underlying LOAD.
Journal ArticleDOI
Genetic analysis of genome-wide variation in human gene expression
Michael Morley,Cliona Molony,Teresa M. Weber,Teresa M. Weber,James L. Devlin,Kathryn G. Ewens,Richard S. Spielman,Vivian G. Cheung,Vivian G. Cheung +8 more
TL;DR: This work used microarrays to measure gene expression levels and performed genome-wide linkage analysis for expression levels of 3,554 genes in 14 large families to localize the genetic determinants of these quantitative traits in humans.
Journal ArticleDOI
Mapping the Genetic Architecture of Gene Expression in Human Liver
Eric E. Schadt,Cliona Molony,Eugene Chudin,Ke-Ke Hao,Xia Yang,Pek Yee Lum,Andrew Kasarskis,Bin Zhang,Susanna Wang,Christine Suver,Jun Zhu,Joshua Millstein,Solveig K. Sieberts,John Lamb,Debraj GuhaThakurta,Jonathan M. J. Derry,John D. Storey,Iliana Avila-Campillo,Mark J Kruger,Jason M. Johnson,Carol A. Rohl,Atila van Nas,Margarete Mehrabian,Thomas A. Drake,Aldons J. Lusis,Ryan Smith,F. Peter Guengerich,Stephen C. Strom,Erin G. Schuetz,Thomas H. Rushmore,Roger G. Ulrich +30 more
TL;DR: This genome-wide association study of gene expression resulted in the detection of more than 6,000 associations between SNP genotypes and liver gene expression traits, where many of the corresponding genes identified have already been implicated in a number of human diseases.
Journal ArticleDOI
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Tthomas W. Winkler,Llu Qi,Valgerdur Ssteinthorsdottir,Ggudmar Tthorleifsson,Ccarola Zillikens,Eelizabeth K. Sspeliotes,Eelizabeth K. Sspeliotes,Reedik Mägi,Tsegaselassie Workalemahu,Charles S. White,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tamara B. Harris,Ssonja I. Berndt,Eerik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Ssailaja Vedantam,Ssailaja Vedantam,Tõnu Eesko,Tuomas O. Kilpeläinen,Zoltán Kutalik,Zoltán Kutalik,Sshengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,J L Min,Miriam F. Moffatt,Cliona Molony,Ggeorge Nicholson,Eeric E. Sschadt,Eeric E. Sschadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eeleanor Wheeler,Andrew R. Wood,Karol Eestrada,Micheal E. Goddard,Micheal E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Sshaun Purcell,Sshaun Purcell,Albert Vernon Ssmith,Peter M. Visscher,Jian Yang,Ssteven A. McCcarroll,Ssteven A. McCcarroll,James Nemesh,Benjamin F. Voight,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy Heard-Ccosta,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Toby Johnson,Toby Johnson,Marika Kaakinen,Karen Kapur,Karen Kapur,Sshamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Micheal F. Leitzmann,Barbara McKknight,Andrew P. Morris,Ken Oong,John R. B. Perry,Marjolein J. Peters,Oozren Polasek,Inga Prokopenko,Nigel W. Rayner,Ssamuli Ripatti,Ssamuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Ida Surakka,Alexander Teumer,Sophie H. Van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Peter S. Chines,Eeva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Kaisa Silander,Klaus Stark,Mari Lliis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John Oolov Jansson,Johannes Kettunen,Johannes Kettunen,Robert Wlawrence,Niina Pellikka,Niina Pellikka,Markus Perola,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N. M. Day,Mariano Dei,Marcus Dörr,Paul Eelliott,Paul Eelliott,Michael R. Eerdos,Johan G. Eeriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Eeco J.C. Geus,Anette P. Gjesing,Harald Grallert,Jürgen Gräßler,Christopher J. Groves,Candace Guiducci,Anna Lliisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eeero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Oolivier Lantieri,Mark Lathrop,Marja Llokki Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne McCcarthy,Mario A. Morken,Mari Nelis,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Llaving,Maris Teder-Llaving,Brian Thomson,Gianluca Usala,Joyce B.J. Van Mmeurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,Bragi Walters,Eelisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Deniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,John Beilby,Alan L. James,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Micheal Stumvoll,Anke Tönjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Ddavey Smith,Shah Eebrahim,Philippe Froguel,Philippe Froguel,Philippe Froguel,Torben Hansen,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay Ttee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Michel Marre,Thomas Meitinger,Andres Metspalu,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Eeric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eeiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Carlos Iribarren,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Igor Rudan,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ann Cchristine Syvanen,Manuela Uda,André G. Uitterlinden,Henry Völzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,M Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Cconnell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Joel N. Hirschhorn,Themistocles L. Assimes,H. Eerich Wichmann,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia Van Dduijn,Kari Stefansson,Kari Stefansson,Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Inês Barroso,Mark I. McCcarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +355 more
TL;DR: A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Thomas W. Winkler,Lu Qi,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,M. Carola Zillikens,Elizabeth K. Speliotes,Reedik Maegi,Tsegaselassie Workalemahu,Charles C. White,Nabila Bouatia-Naji,Tamara B. Harris,Sonja I. Berndt,Erik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Sailaja Vedantam,Tõnu Esko,Tuomas O. Kilpelaeinen,Zoltán Kutalik,Shengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,Josine L. Min,Miriam F. Moffatt,Cliona Molony,George Nicholson,Eric E. Schadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eleanor Wheeler,Andrew R. Wood,Karol Estrada,Michael E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Shaun Purcell,Albert V. Smith,Peter M. Visscher,Jian Yang,Steven A. McCarroll,James Nemesh,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy L. Heard-Costa,Jouke-Jan Hottenga,Åsa Johansson,Toby Johnson,Marika Kaakinen,Karen Kapur,Shamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Michael F. Leitzmann,Barbara McKnight,Andrew P. Morris,Ken K. Ong,John R. B. Perry,Marjolein J. Peters,Ozren Polasek,Inga Prokopenko,Nigel W. Rayner,Samuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Alexander Teumer,Sophie van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Peter S. Chines,Eva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Klaus Stark,Mari-Liis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Johannes Kettunen,Robert Lawrence,Niina Pellikka,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N.M. Day,Mariano Dei,Marcus Doerr,Paul Elliott,Michael R. Erdos,Johan G. Eriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Eco J. C. de Geus,Anette P. Gjesing,Harald Grallert,Juergen Graessler,Christopher J. Groves,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,G. Mark Lathrop,Marja-Liisa Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne Marie McCarthy,Mario A. Morken,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Laving,Brian Thomson,Gianluca Usala,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Michael Stumvoll,Anke Toenjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Davey Smith,Shah Ebrahim,Philippe Froguel,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay-Tee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Thomas Meitinger,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Alan R. Shuldiner,Nicole Soranzo,Tim D. Spector,Ann-Christine Syvänen,Manuela Uda,André G. Uitterlinden,Henry Voelzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Themistocles L. Assimes,H-Erich Wichmann,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Kari Stefansson,L. Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Mark I. McCarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +299 more