Mascha Binder

TL;DR: In this paper, the adaptive immunity in COVID-19 patients with active infection or after recovery and created a repository of currently >14 million B and T-cell receptor (BCR and TCR) sequences from the blood of these patients.

TL;DR: It is demonstrated that the SARS-CoV-2 spike contains sequence and structure motifs highly similar to those of a bacterial superantigen and may directly bind T cell receptors, and the TCR repertoire in adult COVID-19 patients demonstrates that those with severe hyperinflammatory disease exhibit TCR skewing consistent withsuperantigen activation.

TL;DR: In this article, the authors characterized the TCR repertoire of multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome associated with SARS-CoV-2 infection, and found a profound expansion of TCRβ variable gene 11-2, with up to 24% of clonal T cell space occupied by TRBV11-2 T cells, which correlated with MIS-C severity and serum cytokine levels.

TL;DR: In this article, the role of the lung-specific immune response was investigated by profiling immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 patients with severe disease and bacterial pneumonia patients not associated with viral infection.

TL;DR: In this article, the authors used proteomics, RNA sequencing, autoantibody arrays, and B cell receptor (BCR) repertoire analysis to characterize MIS-C immunopathogenesis and identify factors contributing to severe manifestations and intensive care unit admission.