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Daniela Capello
Researcher at University of Eastern Piedmont
Publications - 155
Citations - 8002
Daniela Capello is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Lymphoma & Chronic lymphocytic leukemia. The author has an hindex of 46, co-authored 150 publications receiving 7551 citations. Previous affiliations of Daniela Capello include University of Turin.
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Journal ArticleDOI
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Giulia Fabbri,Silvia Rasi,Davide Rossi,Vladimir Trifonov,Hossein Khiabanian,Jing Ma,Adina Grunn,Marco Fangazio,Daniela Capello,Sara Monti,Stefania Cresta,Ernesto Gargiulo,Francesco Forconi,Anna Guarini,Luca Arcaini,Marco Paulli,Luca Laurenti,Luigi Maria Larocca,Roberto Marasca,Valter Gattei,David Oscier,Francesco Bertoni,Charles G. Mullighan,Robin Foà,Laura Pasqualucci,Raul Rabadan,Riccardo Dalla-Favera,Gianluca Gaidano +27 more
TL;DR: Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.
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Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
Davide Rossi,Silvia Rasi,Giulia Fabbri,Valeria Spina,Marco Fangazio,Francesco Forconi,Roberto Marasca,Luca Laurenti,Alessio Bruscaggin,Michaela Cerri,Sara Monti,Stefania Cresta,Rosella Famà,Lorenzo De Paoli,Pietro Bulian,Valter Gattei,Anna Guarini,Silvia Deaglio,Daniela Capello,Raul Rabadan,Laura Pasqualucci,Riccardo Dalla-Favera,Robin Foà,Gianluca Gaidano +23 more
TL;DR: NotCH1 mutations are an independent predictor of CLL OS, tend to be mutually exclusive with TP53 abnormalities, and identify cases with a dismal prognosis, which is attributable to shorter treatment-free survival and higher risk of Richter transformation.
Journal ArticleDOI
The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.
Davide Rossi,Michaela Cerri,Clara Deambrogi,Elisa Sozzi,Stefania Cresta,Silvia Rasi,Lorenzo De Paoli,Valeria Spina,Valter Gattei,Daniela Capello,Francesco Forconi,Francesco Lauria,Gianluca Gaidano +12 more
TL;DR: TP53 mutations are an independent predictor of short survival and chemorefractoriness, and CLL presenting with TP53 mutations without del 17p13 fare as poorly as CLL carrying del17p13, respectively.
Journal ArticleDOI
Hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
Manel Esteller,Manel Esteller,Gianluca Gaidano,Steven N. Goodman,Vittorina Zagonel,Daniela Capello,Barbara Botto,Davide Rossi,Annunziata Gloghini,Umberto Vitolo,Antonino Carbone,Stephen B. Baylin,James G. Herman +12 more
TL;DR: MGMT promoter hypermethylation appears to be a useful marker for predicting survival in patients with B-DLCL treated with multidrug regimens including cyclophosphamide, and stronger than established prognostic factors, such as age, disease stage, serum lactic dehydrogenase level, and performance status.
Journal ArticleDOI
Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus–related lymphomas
Antonino Carbone,Annunziata Gloghini,Luigi Maria Larocca,Daniela Capello,Francesco Pierconti,Vincenzo Canzonieri,Umberto Tirelli,Riccardo Dalla-Favera,Gianluca Gaidano +8 more
TL;DR: Analysis of nonneoplastic lymph nodes showed that the 3 phenotypic patterns detected in AIDS-NHL and HIV-HL correspond to distinct stages of physiologic B-cell development-centroblasts, which may provide novel tools for refining the diagnosis of these disorders.