M
Marco Fangazio
Researcher at Columbia University
Publications - 35
Citations - 3407
Marco Fangazio is an academic researcher from Columbia University. The author has contributed to research in topics: Chronic lymphocytic leukemia & Diffuse large B-cell lymphoma. The author has an hindex of 16, co-authored 33 publications receiving 3059 citations. Previous affiliations of Marco Fangazio include University of Eastern Piedmont.
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Journal ArticleDOI
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Giulia Fabbri,Silvia Rasi,Davide Rossi,Vladimir Trifonov,Hossein Khiabanian,Jing Ma,Adina Grunn,Marco Fangazio,Daniela Capello,Sara Monti,Stefania Cresta,Ernesto Gargiulo,Francesco Forconi,Anna Guarini,Luca Arcaini,Marco Paulli,Luca Laurenti,Luigi Maria Larocca,Roberto Marasca,Valter Gattei,David Oscier,Francesco Bertoni,Charles G. Mullighan,Robin Foà,Laura Pasqualucci,Raul Rabadan,Riccardo Dalla-Favera,Gianluca Gaidano +27 more
TL;DR: Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.
Journal ArticleDOI
Genetics of Follicular Lymphoma Transformation
Laura Pasqualucci,Hossein Khiabanian,Marco Fangazio,Mansi Vasishtha,Monica Messina,Antony B. Holmes,Peter Ouillette,Vladimir Trifonov,Davide Rossi,Fabrizio Tabbò,Maurilio Ponzoni,Amy Chadburn,Vundavalli V. Murty,Govind Bhagat,Gianluca Gaidano,Giorgio Inghirami,Sami N. Malek,Raul Rabadan,Riccardo Dalla-Favera +18 more
TL;DR: The genomic profile of tFL shares similarities with that of germinal center B cell-type de novo DLBCL but also displays unique combinations of altered genes with diagnostic and therapeutic implications.
Journal ArticleDOI
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
Davide Rossi,Silvia Rasi,Giulia Fabbri,Valeria Spina,Marco Fangazio,Francesco Forconi,Roberto Marasca,Luca Laurenti,Alessio Bruscaggin,Michaela Cerri,Sara Monti,Stefania Cresta,Rosella Famà,Lorenzo De Paoli,Pietro Bulian,Valter Gattei,Anna Guarini,Silvia Deaglio,Daniela Capello,Raul Rabadan,Laura Pasqualucci,Riccardo Dalla-Favera,Robin Foà,Gianluca Gaidano +23 more
TL;DR: NotCH1 mutations are an independent predictor of CLL OS, tend to be mutually exclusive with TP53 abnormalities, and identify cases with a dismal prognosis, which is attributable to shorter treatment-free survival and higher risk of Richter transformation.
Journal ArticleDOI
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness.
Davide Rossi,Alessio Bruscaggin,Valeria Spina,Silvia Rasi,Hossein Khiabanian,Monica Messina,Marco Fangazio,Tiziana Vaisitti,Sara Monti,Sabina Chiaretti,Anna Guarini,Ilaria Del Giudice,Michaela Cerri,Stefania Cresta,Clara Deambrogi,Ernesto Gargiulo,Valter Gattei,Francesco Forconi,Francesco Bertoni,Silvia Deaglio,Raul Rabadan,Laura Pasqualucci,Laura Pasqualucci,Robin Foà,Riccardo Dalla-Favera,Gianluca Gaidano +25 more
TL;DR: In fludarabine-refractory CLL, SF3B1 mutations and TP53 disruption distributed in a mutually exclusive fashion points to splicing regulation as a novel pathogenetic mechanism of potential clinical relevance in CLL.
Journal ArticleDOI
The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development
Davide Rossi,Vladimir Trifonov,Marco Fangazio,Alessio Bruscaggin,Silvia Rasi,Valeria Spina,Sara Monti,Tiziana Vaisitti,Francesca Arruga,Rosella Famà,Carmela Ciardullo,Mariangela Greco,Stefania Cresta,Daniela Piranda,Antony B. Holmes,Giulia Fabbri,Monica Messina,Andrea Rinaldi,Jiguang Wang,Claudio Agostinelli,Pier Paolo Piccaluga,Marco Lucioni,Fabrizio Tabbò,Roberto Serra,Silvia Franceschetti,Clara Deambrogi,Giulia Daniele,Valter Gattei,Roberto Marasca,Fabio Facchetti,Luca Arcaini,Giorgio Inghirami,Francesco Bertoni,Stefano Pileri,Silvia Deaglio,Robin Foà,Riccardo Dalla-Favera,Laura Pasqualucci,Raul Rabadan,Gianluca Gaidano +39 more
TL;DR: Notch2 mutations represent the most frequent lesion in splenic marginal zone lymphoma and are associated with atypical granuloma-like lesions.