Daqiang Sun

TL;DR: These findings demonstrate that the brain changes are not explained by exposure to antipsychotic drugs but likely play a role in psychosis pathophysiology.

TL;DR: In this article, the authors followed individuals at high-risk for psychosis to determine whether structural changes in the cerebral cortex occur with the onset of psychosis, and they hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis.

TL;DR: In this paper, the authors reviewed genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder and concluded that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity.

TL;DR: First evidence that brain morphology differs meaningfully as a function of reciprocal genomic variation at the 22q11.2 locus is provided, suggesting this genomic region is a genomic region associated with gene-dose-dependent brain phenotypes.