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Ariana Vajdi
Researcher at Semel Institute for Neuroscience and Human Behavior
Publications - 15
Citations - 406
Ariana Vajdi is an academic researcher from Semel Institute for Neuroscience and Human Behavior. The author has contributed to research in topics: Psychosis & Population. The author has an hindex of 7, co-authored 13 publications receiving 260 citations. Previous affiliations of Ariana Vajdi include University of California, Los Angeles.
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Journal ArticleDOI
Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size.
Daqiang Sun,Daqiang Sun,Christopher R.K. Ching,Christopher R.K. Ching,Christopher R.K. Ching,Amy Lin,Amy Lin,Jennifer K. Forsyth,Jennifer K. Forsyth,Leila Kushan,Ariana Vajdi,Maria Jalbrzikowski,Laura Hansen,Julio E. Villalon-Reina,Xiaoping Qu,Rachel K. Jonas,Rachel K. Jonas,Therese van Amelsvoort,Geor Bakker,Wendy R. Kates,Kevin M. Antshel,Wanda Fremont,Linda E. Campbell,Kathryn McCabe,Kathryn McCabe,Eileen Daly,Maria Gudbrandsen,Clodagh M. Murphy,Declan G. Murphy,Michael C. Craig,Michael C. Craig,Jacob A. S. Vorstman,Jacob A. S. Vorstman,Jacob A. S. Vorstman,Ania Fiksinski,Sanne Koops,Kosha Ruparel,David R. Roalf,Raquel E. Gur,Raquel E. Gur,J. Eric Schmitt,J. Eric Schmitt,Tony J. Simon,Naomi J. Goodrich-Hunsaker,Naomi J. Goodrich-Hunsaker,Courtney A. Durdle,Anne S. Bassett,Eva W.C. Chow,Eva W.C. Chow,Nancy J. Butcher,Nancy J. Butcher,Fidel Vila-Rodriguez,Joanne L. Doherty,Adam C. Cunningham,Marianne Bernadette van den Bree,David Edmund Johannes Linden,Hayley Moss,Michael John Owen,Kieran C. Murphy,Donna M. McDonald-McGinn,Donna M. McDonald-McGinn,Beverly S. Emanuel,Beverly S. Emanuel,Theo G.M. van Erp,Jessica A. Turner,Paul M. Thompson,Carrie E. Bearden,Carrie E. Bearden +67 more
TL;DR: A robust neuroanatomic signature of 22q11DS is found, and the first evidence that deletion size impacts brain structure is shown, to support the suitability of this single genetic etiology as a biological model of schizophrenia.
Journal ArticleDOI
Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry.
Amy Lin,Christopher R.K. Ching,Christopher R.K. Ching,Ariana Vajdi,Daqiang Sun,Rachel K. Jonas,Maria Jalbrzikowski,Leila Kushan-Wells,Laura Hansen,Emma Krikorian,Boris A. Gutman,Deepika Dokoru,Gerhard Helleman,Paul M. Thompson,Carrie E. Bearden,Carrie E. Bearden +15 more
TL;DR: First evidence that brain morphology differs meaningfully as a function of reciprocal genomic variation at the 22q11.2 locus is provided, suggesting this genomic region is a genomic region associated with gene-dose-dependent brain phenotypes.
Journal ArticleDOI
Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study
Julio E. Villalon-Reina,Kenia Martínez,Kenia Martínez,Xiaoping Qu,Christopher R.K. Ching,Christopher R.K. Ching,Talia M. Nir,Deydeep Kothapalli,Conor K. Corbin,Daqiang Sun,Daqiang Sun,Amy Lin,Jennifer K. Forsyth,Jennifer K. Forsyth,Leila Kushan,Ariana Vajdi,Maria Jalbrzikowski,Laura Hansen,Rachel K. Jonas,Therese van Amelsvoort,Geor Bakker,Wendy R. Kates,Kevin M. Antshel,Wanda Fremont,Linda E. Campbell,Kathryn McCabe,Kathryn McCabe,Eileen Daly,Maria Gudbrandsen,Clodagh M. Murphy,Declan G. Murphy,Michael C. Craig,Michael C. Craig,Beverly S. Emanuel,Donna M. McDonald-McGinn,Jacob A. S. Vorstman,Jacob A. S. Vorstman,Ania Fiksinski,Ania Fiksinski,Ania Fiksinski,Sanne Koops,Kosha Ruparel,David R. Roalf,Raquel E. Gur,J. Eric Schmitt,Tony J. Simon,Naomi J. Goodrich-Hunsaker,Naomi J. Goodrich-Hunsaker,Naomi J. Goodrich-Hunsaker,Courtney A. Durdle,Joanne L. Doherty,Adam C. Cunningham,Marianne Bernadette van den Bree,David Edmund Johannes Linden,Michael John Owen,Hayley Moss,Sinead Kelly,Gary Donohoe,Kieran C. Murphy,C. Arango,C. Arango,Neda Jahanshad,Paul M. Thompson,Carrie E. Bearden,Carrie E. Bearden +64 more
TL;DR: Findings indicate large effects of the 22q11.2 deletion on WM microstructure, especially in major cortico-cortical connections, may reflect disrupted neurogenesis of projection neurons in outer cortical layers.
Journal ArticleDOI
Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome : Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness
Christopher R.K. Ching,Boris A. Gutman,Daqiang Sun,Julio E Villalon Reina,Anjanibhargavi Ragothaman,Dmitry Isaev,Artemis Zavaliangos-Petropulu,Amy Lin,Rachel K. Jonas,Leila Kushan,Laura Pacheco-Hansen,Ariana Vajdi,Jennifer K. Forsyth,Maria Jalbrzikowski,Geor Bakker,Therese van Amelsvoort,Kevin M. Antshel,Wanda Fremont,Wendy R. Kates,Linda E. Campbell,Kathryn McCabe,Michael C. Craig,Eileen Daly,Maria Gudbrandsen,Clodagh M. Murphy,Declan G. Murphy,Kieran C. Murphy,Ania Fiksinski,Sanne Koops,Jacob A. S. Vorstman,Jacob A. S. Vorstman,Jacob A. S. Vorstman,T. Blaine Crowley,Beverly S. Emanuel,Raquel E. Gur,Donna M. McDonald-McGinn,David R. Roalf,Kosha Ruparel,J. Eric Schmitt,Elaine H. Zackai,Courtney A. Durdle,Naomi J. Goodrich-Hunsaker,Tony J. Simon,Anne S. Bassett,Anne S. Bassett,Nancy J. Butcher,Eva W.C. Chow,Fidel Vila-Rodriguez,Adam C. Cunningham,Joanne L. Doherty,David Edmund Johannes Linden,Hayley Moss,Michael John Owen,Marianne Bernadette van den Bree,Nicolas Crossley,Gabriela M. Repetto,Paul M. Thompson,Carrie E. Bearden +57 more
TL;DR: In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness.
Journal ArticleDOI
Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder.
Amy Lin,Ariana Vajdi,Leila Kushan-Wells,Gerhard Helleman,Laura Hansen,Rachel K. Jonas,Maria Jalbrzikowski,Lyle Kingsbury,Armin Raznahan,Carrie E. Bearden,Carrie E. Bearden +10 more
TL;DR: Cognitive deficits were observed in both CNV groups, with the lowest IQs in deletion carriers, and processing speed impairments implicate aberrant development of the cortical mantle in the pathology underlying impaired processing speed ability.