L
Leila Kushan-Wells
Researcher at Semel Institute for Neuroscience and Human Behavior
Publications - 16
Citations - 200
Leila Kushan-Wells is an academic researcher from Semel Institute for Neuroscience and Human Behavior. The author has contributed to research in topics: Copy-number variation & DiGeorge syndrome. The author has an hindex of 6, co-authored 9 publications receiving 130 citations. Previous affiliations of Leila Kushan-Wells include University of Texas Health Science Center at Houston & University of California, Los Angeles.
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Journal ArticleDOI
Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry.
Amy Lin,Christopher R.K. Ching,Christopher R.K. Ching,Ariana Vajdi,Daqiang Sun,Rachel K. Jonas,Maria Jalbrzikowski,Leila Kushan-Wells,Laura Hansen,Emma Krikorian,Boris A. Gutman,Deepika Dokoru,Gerhard Helleman,Paul M. Thompson,Carrie E. Bearden,Carrie E. Bearden +15 more
TL;DR: First evidence that brain morphology differs meaningfully as a function of reciprocal genomic variation at the 22q11.2 locus is provided, suggesting this genomic region is a genomic region associated with gene-dose-dependent brain phenotypes.
Journal ArticleDOI
Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects
Yingjie Zhao,Alexander Diacou,H. Richard Johnston,Fadi I Musfee,Donna M. McDonald-McGinn,Donna M. McDonald-McGinn,Daniel E. McGinn,Daniel E. McGinn,T. Blaine Crowley,T. Blaine Crowley,Gabriela M. Repetto,Ann Swillen,Jeroen Breckpot,Joris Vermeesch,Wendy R. Kates,M. Cristina Digilio,Marta Unolt,Bruno Marino,Maria Pontillo,Marco Armando,Fabio Di Fabio,Stefano Vicari,Marianne Bernadette van den Bree,Hayley Moss,Michael John Owen,Kieran C. Murphy,Clodagh M. Murphy,Clodagh M. Murphy,Declan G. Murphy,Declan G. Murphy,Kelly Schoch,Vandana Shashi,Flora Tassone,Tony J. Simon,Robert J. Shprintzen,Linda E. Campbell,Nicole Philip,Damian Heine-Suñer,Sixto García-Miñaur,Luis Fernández,Stylianos E. Antonarakis,Massimo Biondi,Erik Boot,Elemi J. Breetvelt,Tiffany Busa,Nancy Butcher,Antonino Buzzanca,Miri Carmel,Isabelle Cleynen,David Cutler,B Dallapiccola,María Angeles de la Fuente Sanches,Michael P. Epstein,Rens Evers,Rosemarie Fritsch,Fernando García Algas,Tingwei Guo,Raquel E. Gur,Matthew S. Hestand,Tracy Heung,Stephen R. Hooper,Andrea Jin,Leila Kushan-Wells,Alejandra Laorden-Nieto,Guido Lattanzi,Christian R. Marshall,Kathryn McCabe,Elena Michaelovsky,Claudia Ornstein,Candice K. Silversides,Oanh Tran,Esther D. A. van Duin,Elfi Vergaelen,Steve Warren,Ronnie Weinberger,Abraham Weizman,Zhengdong Zhang,Michael E. Zwick,Carrie E. Bearden,Claudia Vingerhoets,Therese van Amelsvoort,Stephan Eliez,Maude Schneider,Jacob A. S. Vorstman,Doron Gothelf,Elaine H. Zackai,Elaine H. Zackai,A. J. Agopian,Raquel E. Gur,Raquel E. Gur,Anne S. Bassett,Anne S. Bassett,Beverly S. Emanuel,Beverly S. Emanuel,Elizabeth Goldmuntz,Elizabeth Goldmuntz,Laura E. Mitchell,Tao Wang,Bernice E. Morrow +98 more
TL;DR: Variance in CTD penetrance in the 22q11.2DS population can be explained in part by variants affecting CRKL expression, especially in patients with nested LCR22C-D deletions.
Journal ArticleDOI
Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder.
Amy Lin,Ariana Vajdi,Leila Kushan-Wells,Gerhard Helleman,Laura Hansen,Rachel K. Jonas,Maria Jalbrzikowski,Lyle Kingsbury,Armin Raznahan,Carrie E. Bearden,Carrie E. Bearden +10 more
TL;DR: Cognitive deficits were observed in both CNV groups, with the lowest IQs in deletion carriers, and processing speed impairments implicate aberrant development of the cortical mantle in the pathology underlying impaired processing speed ability.
Journal ArticleDOI
Deletion size analysis of 1680 22q11.2DS subjects identifies a new recombination hotspot on chromosome 22q11.2.
Tingwei Guo,Alexander Diacou,Hiroko Nomaru,Donna M. McDonald-McGinn,Matthew S. Hestand,Wolfram Demaerel,Liangtian Zhang,Yingjie Zhao,Francisco Ujueta,Jidong Shan,Cristina Montagna,Deyou Zheng,Terrence B. Crowley,Leila Kushan-Wells,Carrie E. Bearden,Wendy R. Kates,Doron Gothelf,Maude Schneider,Stephan Eliez,Jeroen Breckpot,Ann Swillen,Jacob A. S. Vorstman,Elaine H. Zackai,Felipe Benavides Gonzalez,Gabriela M. Repetto,Beverly S. Emanuel,Anne S. Bassett,Joris Vermeesch,Christian R. Marshall,Bernice E. Morrow,Behavior Consortia +30 more
TL;DR: LCR22A+ maps to an evolutionary breakpoint between mice and humans and appears to serve as a local hotspot for chromosome rearrangements on 22q11.2DS, serving as recombination hotspots for meiotic chromosomal rearrangement.
Journal ArticleDOI
Genome-Wide Association Study to Find Modifiers for Tetralogy of Fallot in the 22q11.2 Deletion Syndrome Identifies Variants in the GPR98 Locus on 5q14.3
Tingwei Guo,Gabriela M. Repetto,Donna M. McDonald McGinn,Jonathan H. Chung,Hiroko Nomaru,Christopher L. Campbell,Anna Blonska,Anne S. Bassett,Eva W.C. Chow,Elisabeth E. Mlynarski,Ann Swillen,Joris Vermeesch,K Devriendt,Doron Gothelf,Miri Carmel,Elena Michaelovsky,Maude Schneider,S Eliez,Stylianos E. Antonarakis,Karlene Coleman,Aoy Tomita-Mitchell,Michael E. Mitchell,M. Cristina Digilio,B Dallapiccola,Bruno Marino,Nicole Philip,Tiffany Busa,Leila Kushan-Wells,Carrie E. Bearden,Małgorzata Piotrowicz,Wanda Hawuła,Amy E. Roberts,Flora Tassone,Tony J. Simon,Esther D. A. van Duin,Therese van Amelsvoort,Wendy R. Kates,Elaine H. Zackai,H. Richard Johnston,David J. Cutler,A. J. Agopian,Elizabeth Goldmuntz,Laura E. Mitchell,Tao Wang,Beverly S. Emanuel,Bernice E. Morrow +45 more
TL;DR: Common variants may contribute to TOF in 22q11.2DS and may function in cardiac outflow tract development, according to genome-wide association study using Affymetrix 6.3.0 array and imputed genotype data.