Daria Klusa

TL;DR: The central metabolic adaptations in prostate tumors, state-of-the-art technologies for metabolic analysis, and the perspectives for metabolic targeting and diagnostic implications are summarized.

TL;DR: In this article, a review of current clinical concepts for metastatic prostate cancer patients is presented, which discusses the implementation of recent preclinical findings improving our understanding of metastatic dissemination and radiotherapy resistance into standard of care.

TL;DR: In this article , the authors analyzed CSC marker dynamics in prostate cancer, head and neck cancer, and glioblastoma cells upon proton beam irradiation and found that proton irradiation has a higher potential to target CSCs through induction of complex DNA damages, lower rates of cellular senescence, and minor alteration in histone methylation pattern compared with conventional photon irradiation.

TL;DR: It is found that the ALDH+ population outcompetes ALDH- cells and drives tumor growth, in particular upon irradiation, and may be responsible for radiotherapy failure.

TL;DR: In this paper , the authors hypothesize that markers indicative of radioresistance, stemness and/or bone tropism may have a prognostic potential to identify patients profiting from metastases-directed radiotherapy.