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Darren J. Baker
Researcher at Mayo Clinic
Publications - 80
Citations - 15949
Darren J. Baker is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Aneuploidy. The author has an hindex of 39, co-authored 69 publications receiving 11756 citations.
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Journal ArticleDOI
Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders
Darren J. Baker,Tobias Wijshake,Tamar Tchkonia,Nathan K. LeBrasseur,Bennett G. Childs,Bart van de Sluis,James L. Kirkland,Jan M. van Deursen +7 more
TL;DR: Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.
Journal ArticleDOI
Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
Darren J. Baker,Bennett G. Childs,Matej Durik,Melinde Wijers,Cynthia J. Sieben,Jian Zhong,Rachel A. Saltness,Karthik B. Jeganathan,Grace C Verzosa,Abdulmohammad Pezeshki,Khashayarsha Khazaie,Jordan D. Miller,Jan M. van Deursen +12 more
TL;DR: It is shown that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds and the clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects.
Journal ArticleDOI
Cellular senescence in aging and age-related disease: from mechanisms to therapy
TL;DR: Current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy are discussed.
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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Ok-Hee Jeon,Chaekyu Kim,Chaekyu Kim,Remi-Martin Laberge,Marco Demaria,Marco Demaria,Sona Rathod,Alain Philippe Vasserot,Jae Wook Chung,Do Hun Kim,Yan Poon,Nathaniel David,Darren J. Baker,Jan M. van Deursen,Judith Campisi,Judith Campisi,Jennifer H. Elisseeff +16 more
TL;DR: It is found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these cells attenuated the development of post-traumatic OA, reduced pain and increased cartilage development, which support the use of SnCs as a therapeutic target for treating degenerative joint disease.
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Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Bennett G. Childs,Darren J. Baker,Tobias Wijshake,Tobias Wijshake,Cheryl A. Conover,Judith Campisi,Judith Campisi,Jan M. van Deursen +7 more
TL;DR: It is found that foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis, where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines.