D
Dave Hill
Researcher at Amgen
Publications - 4
Citations - 5474
Dave Hill is an academic researcher from Amgen. The author has contributed to research in topics: Genetically modified mouse & FGF18. The author has an hindex of 4, co-authored 4 publications receiving 5263 citations.
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Journal ArticleDOI
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
William S. Simonet,David L. Lacey,Colin R. Dunstan,Michael J. Kelley,Ming-Shi Chang,R Lüthy,Hung Q. Nguyen,S Wooden,L Bennett,Tom Boone,Grant Shimamoto,Margaret L. DeRose,Robin Elliott,Anne Colombero,Hong-Lin Tan,Geraldine Trail,John K. Sullivan,E. Davy,N. Bucay,L Renshaw-Gegg,T.M Hughes,Dave Hill,W Pattison,Patricia Shehan Campbell,S Sander,Gwyneth Van,John E. Tarpley,P Derby,Richard Lee,William J. Boyle +29 more
TL;DR: Data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
Journal ArticleDOI
A Model of Myelofibrosis and Osteosclerosis in Mice Induced by Overexpressing Thrombopoietin (mpl Ligand): Reversal of Disease by Bone Marrow Transplantation
TL;DR: Levels of both transforming growth factor-beta 1 and platelet-derived growth factor are increased twofold to fivefold in the Platelet-poor plasma of TPO overexpressing mice compared with control mice, suggesting that the increased megakaryocytes produce elevated levels of these cytokines that lead to the pathogenesis of disease.
Journal ArticleDOI
FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation.
Mickey C.-T. Hu,Wan R. Qiu,You-ping Wang,Dave Hill,Brian D. Ring,Sheila Scully,Brad Bolon,Margaret L. DeRose,Roland Luethy,W. Scott Simonet,Tsutomu Arakawa,Dimitry M. Danilenko +11 more
TL;DR: Cloning a novel member of the FGF family that is expressed primarily in the lungs and kidneys and at lower levels in the heart, testes, spleen, skeletal muscle, and brain suggests that FGF-18 is a pleiotropic growth factor that stimulates proliferation in a number of tissues.
Journal ArticleDOI
The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction.
Brad Bolon,Shuqian Jing,Frank Asuncion,Sheila Scully,Marlese Pisegna,Gwyneth Van,Zheng Hu,Yan Bin Yu,Hosung Min,Ken Wild,Robert Rosenfeld,John E. Tarpley,Josette Carnahan,Diane Duryea,Dave Hill,Steve Kaufman,Xiao-Qiang Yan,Todd Juan,Kathy Christensen,James McCabe,W. Scott Simonet +20 more
TL;DR: It is confirmed that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and indicate that ART is not a suitable therapy for peripheral neuropathy.