R
Richard Lee
Researcher at Amgen
Publications - 7
Citations - 5314
Richard Lee is an academic researcher from Amgen. The author has contributed to research in topics: Peptide sequence & Osteoclast. The author has an hindex of 5, co-authored 7 publications receiving 5111 citations.
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Journal ArticleDOI
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
William S. Simonet,David L. Lacey,Colin R. Dunstan,Michael J. Kelley,Ming-Shi Chang,R Lüthy,Hung Q. Nguyen,S Wooden,L Bennett,Tom Boone,Grant Shimamoto,Margaret L. DeRose,Robin Elliott,Anne Colombero,Hong-Lin Tan,Geraldine Trail,John K. Sullivan,E. Davy,N. Bucay,L Renshaw-Gegg,T.M Hughes,Dave Hill,W Pattison,Patricia Shehan Campbell,S Sander,Gwyneth Van,John E. Tarpley,P Derby,Richard Lee,William J. Boyle +29 more
TL;DR: Data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
Journal ArticleDOI
A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3
Sean Morony,Casey Capparelli,Richard Lee,Grant Shimamoto,Thomas C. Boone,David L. Lacey,Colin R. Dunstan +6 more
TL;DR: The demonstration that cOPG can inhibit bone Resorption suggests that this molecule may be useful in the treatment of diseases including hyperparathyroidism, humoral hypercalcemia of malignancy, osteoporosis, and inflammatory bone disease, which are characterized, in part, by increases in osteoclastic bone resorption.
Journal ArticleDOI
Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells.
Sharon X. Mu,Min Xia,Gary Elliott,Jakob M. Bogenberger,Susan Swift,Larry Bennett,Dawn L Lappinga,Randy Ira Hecht,Richard Lee,Chris Saris +9 more
TL;DR: It is reported that megakaryocyte growth and development factor (MGDF), thrombopoietin [TPO], c-mpl ligand induces differentiation in a majority of mpl-transfected 32D cells, while interleukin (IL)-3 is exclusively mitogenic in this system.
Journal ArticleDOI
Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure.
Mitsuru Haniu,John O. Hui,Yunjen Young,John Le,Viswanatham Katta,Richard Lee,Grant Shimamoto,Michael F. Rohde +7 more
TL;DR: The inter- and intramolecular disulfide linkages of the dimeric molecule of glial cell line-derived neurotrophic factor are determined by a combination of direct peptide analysis and peptides analysis after either partial reduction or partial oxidation of the protein.