D
David A. Hume
Researcher at University of Queensland
Publications - 612
Citations - 66127
David A. Hume is an academic researcher from University of Queensland. The author has contributed to research in topics: Macrophage & Macrophage colony-stimulating factor. The author has an hindex of 113, co-authored 573 publications receiving 59932 citations. Previous affiliations of David A. Hume include University of California, San Diego & University of Oxford.
Papers
More filters
Journal ArticleDOI
Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?
Kieran S. Hadler,Thomas Huber,A. Ian Cassady,Jane E. Weber,Jodie A. Robinson,Allan D. Burrows,Gregory M. Kelly,Luke W. Guddat,David A. Hume,Gerhard Schenk,Jack U. Flanagan +10 more
TL;DR: A new human gene product encoding a metallohydrolase distantly related to the ~55 kDa plant TRAcP was identified and characterised, and may represent an evolutionary link between TRAcPs and Ser/Thr protein phosphatases.
Journal ArticleDOI
Antigen Sampling CSF1R-Expressing Epithelial Cells Are the Functional Equivalents of Mammalian M Cells in the Avian Follicle-Associated Epithelium.
Adam Balic,Cosmin Chintoan-Uta,Prerna Vohra,Kate M. Sutton,Robin L. Cassady-Cain,Tuan Hu,David S. Donaldson,Mark P. Stevens,Neil A. Mabbott,David A. Hume,Helen Sang,Lonneke Vervelde +11 more
TL;DR: The novel expression of CSF1R in birds suggests that these functional equivalents to mammalian M cells may have different ontological origins and their development and function are likely to be regulated by different growth factors.
Journal ArticleDOI
The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes
TL;DR: The addition of terminal dG residues and other minor changes to the potently immunostimulatory PS-ODN 1668S caused delayed signalling and the reduction in immunostIMulatory activity of PS- ODN was associated with a delay in the activation of MAP kinases.
Journal ArticleDOI
The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity.
TL;DR: An overview of the equine mononuclear phagocyte system is provided, describing the variation in the function and phenotype of macrophages depending on their location and the similarities and differences between the rodent, human and equine immune response.
Journal ArticleDOI
Focusing in on structural genomics: The University of Queensland structural biology pipeline
Munish Puri,Gautier Robin,Nathan Cowieson,Jade K. Forwood,Pawel Listwan,Shu-Hong Hu,Gregor Gunčar,Thomas Huber,Stuart Kellie,David A. Hume,Bostjan Kobe,Jennifer L. Martin +11 more
TL;DR: The structures from this pipeline will provide insights into the function of previously uncharacterized macrophage proteins and could lead to the validation of new drug targets for chronic obstructive pulmonary disease and arthritis.