D
David A. Hume
Researcher at University of Queensland
Publications - 612
Citations - 66127
David A. Hume is an academic researcher from University of Queensland. The author has contributed to research in topics: Macrophage & Macrophage colony-stimulating factor. The author has an hindex of 113, co-authored 573 publications receiving 59932 citations. Previous affiliations of David A. Hume include University of California, San Diego & University of Oxford.
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Journal ArticleDOI
Characterisation and Trophic Functions of Murine Embryonic Macrophages Based Upon the Use of a Csf1r-EGFP Transgene Reporter
Fiona K. Rae,Kyra Woods,Tedjo Sasmono,Naomi Vittoria Campanale,Darrin Taylor,Dmitry A. Ovchinnikov,Dmitry A. Ovchinnikov,Sean M. Grimmond,David A. Hume,David A. Hume,Sharon D. Ricardo,Melissa H. Little +11 more
TL;DR: The use of a previously described transgenic line, with EGFP driven by the macrophage-restricted Csf1r (c-fms) promoter, to image Macrophage production and infiltration accompanying organogenesis in many tissues is reported, suggesting a trophic role of macrophages in embryonic kidney development.
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The Colony-Stimulating Factor 1 Receptor Is Expressed on Dendritic Cells during Differentiation and Regulates Their Expansion
Kelli P. A. MacDonald,Vanessa Rowe,Helen M. Bofinger,Ranjeny Thomas,Tedjo Sasmono,David A. Hume,Geoffrey R. Hill +6 more
TL;DR: It is determined that although the c-fms promoter is inactive in DC precursors, it is up-regulated in all DC subsets during differentiation, and this provides additional evidence that the majority of tissue DC is of myeloid origin during steady state.
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Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs.
Norihiro Maeda,Takeya Kasukawa,Rieko Oyama,Julian Gough,Martin C. Frith,Pär G. Engström,Pär G. Engström,Boris Lenhard,Boris Lenhard,Rajith N. Aturaliya,Serge Batalov,Kirk W. Beisel,Carol J. Bult,Colin F. Fletcher,Alistair R. R. Forrest,Masaaki Furuno,David E. Hill,Masayoshi Itoh,Mutsumi Kanamori-Katayama,Shintaro Katayama,Masaru Katoh,Tsugumi Kawashima,John Quackenbush,John Quackenbush,Timothy Ravasi,Brian Z. Ring,Kazuhiro Shibata,Koji Sugiura,Yoichi Takenaka,Rohan D. Teasdale,Christine A. Wells,Yunxia Zhu,Chikatoshi Kai,Jun Kawai,David A. Hume,Piero Carninci,Yoshihide Hayashizaki +36 more
TL;DR: The FANTOM3 annotation system, consisting of automated computational prediction, manualCuration, and final expert curation, facilitated the comprehensive characterization of the mouse transcriptome, and could be applied to the transcriptomes of other species.
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Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses.
Vera M. Ripoll,Katharine M. Irvine,Timothy Ravasi,Matthew J. Sweet,Matthew J. Sweet,David A. Hume +5 more
TL;DR: GPNMB acts as a negative regulator of macrophage inflammatory responses, and DBA mice, which have an inactivating point mutation in the gpnmb gene, exhibited reduced numbers of myeloid cells, elevated numbers of thioglycolate-elicited peritoneal macrophages, and higher levels of proinflammatory cytokines in response to LPS.
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The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.
Katryn J. Stacey,Greg R. Young,Francis Clark,David P. Sester,Tara L. Roberts,Shalin H. Naik,Matthew J. Sweet,David A. Hume +7 more
TL;DR: It is suggested that G-rich sequences such as GGAGGGG, which potently inhibited activation and are found in greater frequency in the mouse than the E. coli genome, combined to explain the inactivity of self DNA.