D
David A. Hume
Researcher at University of Queensland
Publications - 612
Citations - 66127
David A. Hume is an academic researcher from University of Queensland. The author has contributed to research in topics: Macrophage & Macrophage colony-stimulating factor. The author has an hindex of 113, co-authored 573 publications receiving 59932 citations. Previous affiliations of David A. Hume include University of California, San Diego & University of Oxford.
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Journal ArticleDOI
Macrophages as APC and the Dendritic Cell Myth
TL;DR: Evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors, express the same surface markers, and have no unique adaptation for Ag presentation that is not shared by other macrophages is summarized.
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Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome
Timothy Ravasi,Harukazu Suzuki,Ken C Pang,Shintaro Katayama,Masaaki Furuno,Rie Okunishi,Shiro Fukuda,Kelin Ru,Martin C. Frith,Milena Gongora,Sean M. Grimmond,David A. Hume,Yoshihide Hayashizaki,John S. Mattick +13 more
TL;DR: Analysis of the genomic landscape around these sequences indicates that some cDNA clones were produced not from terminal poly(A) tracts but internal priming sites within longer transcripts, only a minority of which is encompassed by known genes.
Journal Article
An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Timothy Ravasi,Harukazu Suzuki,Carlo Vittorio Cannistraci,Shintaro Katayama,Vladimir B. Bajic,Vladimir B. Bajic,Kai Tan,Altuna Akalin,Sebastian Schmeier,Sebastian Schmeier,Mutsumi Kanamori-Katayama,Nicolas Bertin,Piero Carninci,Carsten O. Daub,Alistair R. R. Forrest,Julian Gough,Julian Gough,Sean M. Grimmond,Sean M. Grimmond,Jung Hoon Han,Jung Hoon Han,Takehiro Hashimoto,Winston Hide,Winston Hide,Winston Hide,Oliver Hofmann,Oliver Hofmann,Atanas Kamburov,Atanas Kamburov,Mandeep Kaur,Hideya Kawaji,Atsutaka Kubosaki,Timo Lassmann,Erik van Nimwegen,Erik van Nimwegen,Cameron Ross MacPherson,Chihiro Ogawa,Aleksandar Radovanovic,Ariel S. Schwartz,Rohan D. Teasdale,Rohan D. Teasdale,Jesper Tegnér,Jesper Tegnér,Jesper Tegnér,Boris Lenhard,Sarah A. Teichmann,Sarah A. Teichmann,Takahiro Arakawa,Noriko Ninomiya,Kayoko Murakami,Michihira Tagami,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ryoko Ishihara,Yayoi Kitazume,Jun Kawai,David A. Hume,David A. Hume,Trey Ideker,Yoshihide Hayashizaki +60 more
TL;DR: In this paper, the authors build a global atlas of DNA-binding transcription factor (TF) combinatorial networks and identify a SMAD3/FLI1 complex expressed during development of immunity.
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The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
Harukazu Suzuki,Alistair R. R. Forrest,Erik van Nimwegen,Carsten O. Daub,Piotr J. Balwierz,Katharine M. Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J. L. de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy L. Bailey,Vladimir B. Bajic,Denis C. Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M. Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josée Dostie,Pär G. Engström,Magbubah Essack,Geoffrey J. Faulkner,J. Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M. Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Winston Hide,Oliver Hofmann,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C. Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Ross MacPherson,Norihiro Maeda,Christopher G. Maher,Monique Maqungo,Jessica C. Mar,Nicholas Matigian,Hideo Matsuda,John S. Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S. Schwartz,Colin A. Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,Georges St. Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J. Sweet,Ryan J. Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S. Taylor,Rohan D. Teasdale,Jesper Tegnér,Jesper Tegnér,Sarah A. Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A. Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A. Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki +162 more
TL;DR: The results indicate that cellular states are constrained by complex networks involving both positive and negative regulatory interactions among substantial numbers of transcription factors and that no single transcription factor is both necessary and sufficient to drive the differentiation process.
Journal ArticleDOI
An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
Kelli P. A. MacDonald,James S. Palmer,Stephen L. Cronau,Elke Seppanen,Stuart D. Olver,Neil C. Raffelt,Rachel D. Kuns,Allison R. Pettit,Andrew D. Clouston,Brandon J. Wainwright,D Branstetter,Jeffrey Smith,Raymond J. Paxton,Douglas P. Cerretti,Lynn Bonham,Geoffrey R. Hill,David A. Hume +16 more
TL;DR: The data indicate that CSF1R signaling is required only for the maturation and replacement of resident-type monocytes and tissue macrophages, and is not required for monocyte production or inflammatory function.