David A. Saperstein

TL;DR: In this article, the authors used infrared-laser atomic-force microscopy to reveal the native arrangement of rhodopsin, which forms paracrystalline arrays of dimers in mouse disc membranes.

TL;DR: This is the first semi-empirical model of a higher order structure of a GPCR in native membranes, and it has profound implications for the understanding of how this receptor interacts with partner proteins.

TL;DR: Evidence is provided that adenoviral vector-mediated ocular gene transfer is a viable approach for the treatment of ocular disorders and that further studies investigating the efficacy of AdPEDF.11 in patients with neovascular AMD should be performed.

TL;DR: Based on this large survey, the prevalence of disease‐causing mutations in each of these genes within specific disease categories is estimated and these data are useful in estimating the frequency of specific mutations and in selecting individuals and families for mutation‐specific studies.

TL;DR: A semi‐empirical molecular model for the rhodopsin paracrystal is presented validating the previously reported results and comparing the model with other currently available models describing the supramolecular structure of GPCRs in the membrane.