Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes
Yan Liang,Dimitrios Fotiadis,Slawomir Filipek,David A. Saperstein,Krzysztof Palczewski,Andreas Engel +5 more
TLDR
This is the first semi-empirical model of a higher order structure of a GPCR in native membranes, and it has profound implications for the understanding of how this receptor interacts with partner proteins.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-06-13 and is currently open access. It has received 595 citations till now. The article focuses on the topics: Rhodopsin & Opsin.read more
Citations
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The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific
Douglas B. Rusch,Aaron L. Halpern,Granger G. Sutton,Karla B. Heidelberg,Karla B. Heidelberg,Shannon J. Williamson,Shibu Yooseph,Dongying Wu,Dongying Wu,Jonathan A. Eisen,Jonathan A. Eisen,Jeff Hoffman,Karin A. Remington,Karen Beeson,Bao Duc Tran,Hamilton O. Smith,Holly Baden-Tillson,Clare Stewart,Joyce Thorpe,Jason Freeman,Cynthia Andrews-Pfannkoch,Joseph E. Venter,Kelvin Li,Saul A. Kravitz,John F. Heidelberg,John F. Heidelberg,T. Utterback,Yu-Hui Rogers,Luisa I. Falcón,Valeria Souza,Germán Bonilla-Rosso,Luis E. Eguiarte,David M. Karl,Shubha Sathyendranath,Trevor Platt,Eldredge Bermingham,Victor A. Gallardo,Giselle Tamayo-Castillo,Michael Ferrari,Robert L. Strausberg,Kenneth H. Nealson,Kenneth H. Nealson,Robert Friedman,Marvin Frazier,J. Craig Venter +44 more
TL;DR: A metagenomic study of the marine planktonic microbiota in which surface (mostly marine) water samples were analyzed as part of the Sorcerer II Global Ocean Sampling expedition, which yielded an extensive dataset consisting of 7.7 million sequencing reads.
Journal ArticleDOI
Lipid rafts: at a crossroad between cell biology and physics.
TL;DR: The concept of lipid rafts as it has emerged from the study of synthetic membranes with the reality of lateral heterogeneity in biological membranes is compared.
Journal ArticleDOI
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Jonathan D. Urban,William P. Clarke,Mark von Zastrow,David E. Nichols,Brian K. Kobilka,Harel Weinstein,Jonathan A. Javitch,Bryan L. Roth,Arthur Christopoulos,Patrick M. Sexton,Keith J. Miller,Michael Spedding,Richard B. Mailman +12 more
TL;DR: Besides the heuristically interesting nature of functional selectivity, there is a clear impact on drug discovery, because this mechanism raises the possibility of selecting or designing novel ligands that differentially activate only a subset of functions of a single receptor, thereby optimizing therapeutic action.
Journal ArticleDOI
Molecular Structure and Physiological Functions of GABAB Receptors
TL;DR: Current concepts on the molecular composition and function of GABA(B) receptors are reviewed and ongoing drug-discovery efforts are discussed, which are expected to broaden the spectrum of therapeutic applications.
Journal ArticleDOI
Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.
Oliver P. Ernst,David T. Lodowski,Marcus Elstner,Peter Hegemann,Leonid S. Brown,Hideki Kandori +5 more
TL;DR: Rhodopsins found in Eukaryotes, Bacteria, and Archaea consist of opsin apoproteins and a covalently linked retinal which is employed to absorb photons for energy conversion or the initiation of intra- or intercellular signaling.
References
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TL;DR: Special efforts were made to allow for appropriate display and analysis of the sets of typically 20-40 conformers that are conventionally used to represent the result of an NMR structure determination, using functions for superimposing sets of conformers, calculation of root mean square distance (RMSD) values, identification of hydrogen bonds, and identification and listing of short distances between pairs of hydrogen atoms.
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TL;DR: This article determined the structure of rhodopsin from diffraction data extending to 2.8 angstroms resolution and found that the highly organized structure in the extracellular region, including a conserved disulfide bridge, forms a basis for the arrangement of the sevenhelix transmembrane motif.
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