D
David Clarke
Researcher at University of Edinburgh
Publications - 522
Citations - 26522
David Clarke is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Adaptive control & Model predictive control. The author has an hindex of 70, co-authored 504 publications receiving 24626 citations. Previous affiliations of David Clarke include RMIT University & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
The chemical basis of serine palmitoyltransferase inhibition by myriocin
John M. Wadsworth,David Clarke,Stephen A. McMahon,Jonathan Lowther,Ashley E. Beattie,Patrick R. R. Langridge-Smith,Howard B. Broughton,Teresa M. Dunn,James H. Naismith,Dominic J. Campopiano +9 more
TL;DR: By combining spectroscopy, mass spectrometry, X-ray crystallography, and kinetics, the molecular details of SPT inhibition by myriocin are characterized and this surprising dual mechanism of inhibition rationalizes the extraordinary potency and longevity of myriOCin inhibition.
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Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
Karen Taylor,David Clarke,Bryan J. McCullough,Wuthareth Chin,Emily S. Seo,De Yang,Joost J. Oppenheim,Dušan Uhrín,John R. W. Govan,Dominic J. Campopiano,Derek Macmillan,Perdita E. Barran,Julia R. Dorin +12 more
TL;DR: The chemoattractant and antimicrobial activities of β-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds.
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Garlic Revisited: Antimicrobial Activity of Allicin-Containing Garlic Extracts against Burkholderia cepacia Complex
Daynea Wallock-Richards,Catherine J. Doherty,Lynsey Doherty,David Clarke,Marc Place,John R. W. Govan,Dominic J. Campopiano +6 more
TL;DR: The first evidence that allicin and allicIn-containing garlic extracts possess inhibitory and bactericidal activities against the Burkholderia cepacia complex is reported, suggesting a role for allic in as a general electrophilic reagent that targets protein thiols.
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Increased sensitivity of
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Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity.
Dominic J. Campopiano,David Clarke,Nick C. Polfer,Perdita E. Barran,Ross J. Langley,John R. W. Govan,Alison Maxwell,Julia R. Dorin +7 more
TL;DR: This first description of a covalently cross-linked member of thedefensin family provides further evidence that the antimicrobial activity of a defensin is linked to its ability to form stable higher order structures.