D
David E. Levy
Researcher at New York University
Publications - 242
Citations - 38178
David E. Levy is an academic researcher from New York University. The author has contributed to research in topics: Transcription factor & Interferon. The author has an hindex of 97, co-authored 241 publications receiving 35917 citations. Previous affiliations of David E. Levy include National Taiwan University & Spanish National Research Council.
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Journal ArticleDOI
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
Nuria de la Iglesia,Genevieve Konopka,Sidharth V. Puram,Jennifer A. Chan,Robert M. Bachoo,Mingjian James You,David E. Levy,Ronald A. DePinho,Azad Bonni +8 more
TL;DR: It is reported that STAT3 plays a pro-oncogenic or tumor-suppressive role depending on the mutational profile of the tumor, providing the rationale for tailored therapeutic intervention in glioblastoma.
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Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation
TL;DR: Activation of this factor was independent of the normal functioning of Ras, and required the major sites for autophosphorylation on the EGF receptor that bind Src homology region 2 domain-containing proteins implicated in Ras activation.
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Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.
Juerg Schwaller,Evan Parganas,Demin Wang,Danielle Cain,Jon C. Aster,Ifor R. Williams,Chien-Kuo Lee,Rachel Gerthner,Toshio Kitamura,Julie Frantsve,Ema Anastasiadou,Mignon L. Loh,David E. Levy,James N. Ihle,James N. Ihle,D. Gary Gilliland,D. Gary Gilliland +16 more
TL;DR: A critical role is defined for Stat5a/b and mOSM in the pathogenesis of TEL/JAK2 disease by addressing whether STAT5 activation is necessary for the myelo- and lymphoproliferative disease induced by TEL or JAK2 using a genetic approach.
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Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.
TL;DR: Interferon-stimulated gene factor 2 (ISGF2) was purified from HeLa cells treated with alpha interferon and sequence analysis revealed that the ISGF2 protein was the same as that encoded by the cDNA clone IRF-1, which has been claimed to activate transcription ofinterferon genes.
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Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.
TL;DR: It is shown that post-translational activation of ISGF3 in the cytoplasm of IFN-alpha-treated cells requires two cy toplasmic activities to produce an ISRE-binding complex that accumulates in the nucleus, and that these activities are actually distinct subunits of the IS GF3 complex, which associate through noncovalent interaction.