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David J. Carlson
Researcher at University of Pennsylvania
Publications - 78
Citations - 2668
David J. Carlson is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Relative biological effectiveness & Radiation therapy. The author has an hindex of 22, co-authored 71 publications receiving 2222 citations. Previous affiliations of David J. Carlson include Yale University & University of Maryland, Baltimore.
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The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?
TL;DR: It is suggested that for most tumors, the standard radiobiology concepts of the 5 Rs are sufficient to explain the clinical data, and the excellent results obtained from clinical studies are the result of the much larger biologically effective doses that are delivered with SRS and SBRT.
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Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death
Robert D. Stewart,Victor K. Yu,Alexandros G. Georgakilas,Constantinos Koumenis,Joo Han Park,David J. Carlson +5 more
TL;DR: The Monte Carlo Damage Simulation (MCDS) is extended to account for reductions in the initial lesion yield arising from enhanced chemical repair of DNA radicals under hypoxic conditions, and the kinetic energy range and types of particles considered in the MCDS have been expanded to include charged particles up to and including 56Fe ions.
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Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy
Harald Paganetti,Eleanor A. Blakely,A Carabe-Fernandez,David J. Carlson,Indra J. Das,Lei Dong,David R. Grosshans,Kathryn D. Held,Radhe Mohan,Vitali Moiseenko,Andrzej Niemierko,Robert D. Stewart,Henning Willers +12 more
TL;DR: Whether the current clinical practice of using a constant RBE for protons should be revised or maintained and the potential clinical consequences of delivering biologically weighted proton doses based on variable RBE and/or LET models implemented in treatment planning systems are assessed.
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Management of three-dimensional intrafraction motion through real-time DMLC tracking
Amit Sawant,R. Venkat,Vikram Srivastava,David J. Carlson,Sergey Povzner,Herb Cattell,Paul J. Keall +6 more
TL;DR: Early results indicate that accurate, real-time DMLC tracking of 3D tumor motion is feasible and can potentially result in significant geometric and dosimetric advantages leading to more effective management of intrafraction motion.
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Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
TL;DR: Hypofractionation of a radiotherapy regimen can result in a significant decrease in tumor cell killing compared to standard fractionation as a result of tumor hypoxia.