Alexandros G. Georgakilas

TL;DR: The advances made toward understanding the basis of cancer immune evasion are discussed, the efficacy of various therapeutic measures and targets that have been developed or are being investigated to enhance tumor rejection are summarized and some natural agents and phytochemicals merit further study.

TL;DR: The current status of knowledge and evidence on the mechanisms and involvement of intracellular oxidative stress and DNA damage in human malignancy evolution and possible use of these parameters as cancer biomarkers are presented and controversies related to specific methodologies used for the measurement of oxidatively induced DNA lesions in human cells or tissues are discussed.

TL;DR: Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such the authors can hypothesize of potential mode(s) of action) by which oxidative stress modulates epigenetic regulation of gene expression.

TL;DR: This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer.

TL;DR: Natural compounds found to inhibit one or more pathways that contribute to proliferation have been found and will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.