P
Peter A. Greer
Researcher at Queen's University
Publications - 143
Citations - 6773
Peter A. Greer is an academic researcher from Queen's University. The author has contributed to research in topics: Calpain & Tyrosine kinase. The author has an hindex of 44, co-authored 132 publications receiving 6198 citations. Previous affiliations of Peter A. Greer include Mount Sinai Hospital & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division
TL;DR: The physiological roles and possible functional distinctions of μ- and m-calpains remain unclear, but suggested functions include participation in cell division and migration, integrin-mediated signal transduction, apoptosis, and regulation of cellular control proteins such as cyclin D1 and p53.
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Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis
Rana S. Moubarak,Victor J. Yuste,Cédric Artus,Aïda Bouharrour,Peter A. Greer,Josiane Ménissier-de Murcia,Santos A. Susin +6 more
TL;DR: The data shed new light on the mechanisms regulating AIF-dependent necrosis and support the notion that, like apoptosis, necrosis could be a highly regulated cell death program.
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Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts
Nathalie Dourdin,Amit Bhatt,Previn Dutt,Peter A. Greer,J. Simon C. Arthur,John S. Elce,Anna Huttenlocher +6 more
TL;DR: It is demonstrated unequivocally that calpain is a critical regulator of cell migration and of the organization of the actin cytoskeleton and focal adhesions.
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Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit
Jing Yang,Zhuhao Wu,Nicolas Renier,David J. Simon,Kunihiro Uryu,David S. Park,Peter A. Greer,Cathy Tournier,Roger J. Davis,Marc Tessier-Lavigne +9 more
TL;DR: Using traumatic injury as a model, this work systematically investigates mitogen-activated protein kinase (MAPK) families and delineates a MAPK cascade that represents the early degenerative response to axonal injury, revealing a regulatory mechanism that integrates distinct signals to instruct pathological axon degeneration.
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Closing in on the biological functions of Fps/Fes and Fer.
TL;DR: Fps/Fes and Fer are the only known members of a distinct subfamily of the non-receptor protein-tyrosine kinase family that have roles in regulating cytoskeletal rearrangements and inside–out signalling that accompany receptor–ligand, cell–matrix and cell–cell interactions.