D
David Kowbel
Researcher at University of California, Berkeley
Publications - 62
Citations - 5788
David Kowbel is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Gene & Neurospora crassa. The author has an hindex of 30, co-authored 62 publications receiving 5585 citations. Previous affiliations of David Kowbel include University of California, San Francisco & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Daniel Pinkel,Daniel Pinkel,Richard Segraves,Damir Sudar,Steven M. Clark,Ian Poole,David Kowbel,Colin Collins,Wen Lin Kuo,Chira Chen,Ye Zhai,Shanaz H. Dairkee,Britt-Marie Ljung,Joe W. Gray,Joe W. Gray,Donna G. Albertson,Donna G. Albertson,Donna G. Albertson +17 more
TL;DR: The implementation of array CGH is demonstrated to be able to measure copy number with high precision in the human genome, and to analyse clinical specimens by obtaining new information on chromosome 20 aberrations in breast cancer.
Journal ArticleDOI
Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene.
Donna G. Albertson,Bauke Ylstra,Richard Segraves,Colin Collins,Shanaz H. Dairkee,David Kowbel,Wen Lin Kuo,Joe W. Gray,Daniel Pinkel +8 more
TL;DR: It is shown here that quantitative measurement of DNA copy number across amplified regions using array comparative genomic hybridization (CGH) may facilitate oncogene identification by providing precise information on the locations of both amplicon boundaries and amplification maxima.
Journal ArticleDOI
Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma
Colin Collins,Johanna M. Rommens,David Kowbel,Tony E. Godfrey,Minna Tanner,Soo In Hwang,Daniel Polikoff,Genevieve Nonet,Joanne Cochran,Ken Myambo,Karen E. Jay,Jeff Froula,Thomas Cloutier,Wen Lin Kuo,Paul Yaswen,Shanaz H. Dairkee,Jennifer Giovanola,Gordon B. Hutchinson,Jorma Isola,Olli Kallioniemi,Mike Palazzolo,Christopher Martin,Cheryl L. Ericsson,Daniel Pinkel,Daniel Pinkel,Donna G. Albertson,Donna G. Albertson,Wu Bo Li,Joe W. Gray,Joe W. Gray +29 more
TL;DR: The molecular cloning of an approximately 1-Mb region of recurrent amplification at 20q13.2 in breast cancer and other tumors and the delineation of a 260-kb common region of amplification are reported.
Journal ArticleDOI
Population genomics and local adaptation in wild isolates of a model microbial eukaryote
Christopher E. Ellison,Charles Hall,David Kowbel,Juliet W. Welch,Rachel B. Brem,N. L. Glass,John W. Taylor +6 more
TL;DR: One of the genes identified using this unbiased, whole-genome approach is the well-known circadian oscillator frequency, suggesting that the 2.4°–10.6° difference in latitude between the populations may be another important environmental parameter.
Journal Article
Independent Amplification and Frequent Co-Amplification of Three Nonsyntenic Regions on the Long Arm of Chromosome 20 in Human Breast Cancer
Minna Tanner,Mika Tirkkonen,Anne Kallioniemi,Jorma Isola,Tuula Kuukasjärvi,Colin Collins,Colin Collins,David Kowbel,David Kowbel,Xin Yuan Guan,Jeff Trent,Joe W. Gray,Joe W. Gray,Paul S. Meltzer,Olli Kallioniemi +14 more
TL;DR: The results suggest that three distinct nonsyntenic regions along 20q may be important and that complex chromosomal rearrangements underlie their frequent co-amplification in breast cancer.