D
David L. Hoffman
Researcher at University of Rochester
Publications - 28
Citations - 2795
David L. Hoffman is an academic researcher from University of Rochester. The author has contributed to research in topics: Hordeum vulgare & Mitochondrion. The author has an hindex of 18, co-authored 26 publications receiving 2662 citations. Previous affiliations of David L. Hoffman include United States Department of Agriculture & University of Rochester Medical Center.
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Journal ArticleDOI
A molecular, isozyme and morphological map of the barley (Hordeum vulgare) genome.
Andris Kleinhofs,A. Kilian,M. A. Saghai Maroof,R. M. Biyashev,Patrick M. Hayes,F. Chen,Nora L. V. Lapitan,A. L. Fenwick,Tom Blake,Vladimir Kanazin,E. Ananiev,L. Dahleen,Dave Kudrna,J. Bollinger,Steven J. Knapp,Liu Bh,Mark E. Sorrells,M. Heun,Jerome D. Franckowiak,David L. Hoffman,R. Skadsen,Brian J. Steffenson +21 more
TL;DR: A map of the barley genome consisting of 295 loci was constructed, which includes 152 cDNA restriction fragment length polymorphism (RFLP), 114 genomic DNA RFLP, 14 random amplified polymorphic DNA (RAPD), five isozyme, two morphological, one disease resistance and seven specific amplicon polymorphism
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Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosis
TL;DR: In this paper, the effect of variable levels of fluoride and calcium intake, accompanied by vitamin D, on osteoporosis in eleven patients treated for one year Bone biopsies indicated an increase in new bone formation in all patients receiving 45 mg of sodium fluoride per day, whereas 600 mg of calcium per day prevented both osteomalacia and any increase in bone resorption.
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The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation
Jennifer R. Hom,Rodrigo A. Quintanilla,David L. Hoffman,Karen L. de Mesy Bentley,Jeffery D. Molkentin,Shey-Shing Sheu,Shey-Shing Sheu,George A. Porter +7 more
TL;DR: The role of mitochondria in the development of the human heart was investigated in this paper, where the authors found that closure of the mitochondrial permeability transition pore (mPTP) drove maturation of mitochondrial structure and function and myocyte differentiation.
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Short- and long-term effects of estrogen and synthetic anabolic hormone in postmenopausal osteoporosis
B. Lawrence Riggs,Jenifer Jowsey,Ralph S. Goldsmith,Patrick J. Kelly,David L. Hoffman,Claude D. Arnaud +5 more
TL;DR: The primary effect of sex hormones in postmenopausal osteoporosis is to decrease the increased level of bone resorption by decreasing the responsiveness of bone to endogenous parathyroid hormone, which is negated after long-term treatment by a secondary decrease in bone formation.
Journal ArticleDOI
Regions of the genome that affect agronomic performance in two-row barley
Nicholas A. Tinker,Diane E. Mather,Brian G. Rossnagel,K. J. Kasha,Andris Kleinhofs,Patrick M. Hayes,D. E. Falk,T. Ferguson,L. P. Shugar,W. G. Legge,R. B. Irvine,T. M. Choo,K. G. Briggs,Steven E. Ullrich,Jerome D. Franckowiak,Tom Blake,Robert J. Graf,S. M. Dofing,M. A. Saghai Maroof,Graham J. Scoles,David L. Hoffman,Lynn S. Dahleen,A. Kilian,F. Chen,R. M. Biyashev,Dave Kudrna,Brian J. Steffenson +26 more
TL;DR: This study was an intensive effort to evaluate QTL in a narrow-base population grown in a large set of environments and reveals the types and distributions of QTL effects manipulated by plant breeders and provides opportunities for future testing of marker-assisted selection.