Karen Holloway

TL;DR: In this article, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen, and one was selected for expression of normal endothelial markers, including CD31, VE cadherin, and von Willebrand factor.

TL;DR: Investigation of the effect of Aβ 1–40 on the permeability of an immortalized human BEC line, hCMEC/D3, suggests that the JNK and p38MAPK pathways might represent attractive therapeutic targets for preventing BBB dysfunction in AD.

TL;DR: Results suggest that expression of chemokine receptor/ligand pairs such as CXCR3/CXCL10 have an important role in the proliferation of glioma cells.

TL;DR: A scheme for endothelial differentiation is identified, in which activation or repression of tissue-specific proteins is maintained by a set of transcription factors which include Sp3 and YY1, which differentially interact with the occludin promoter to induce expression of occluda in brain endothelium and repression in other endothelia.

TL;DR: A model is presented, in which expression from the transferrin receptor gene in endothelium requires the activity of both TFIID and Sp3, but whether the gene is transcribed in different endothelia, is related to the balance between activating and suppressive forms of YY1.