David R. Haft

TL;DR: Recent developments with InterPro are reported, including the addition of two new databases, and the functionality to include residue-level annotation and prediction of intrinsic disorder, which enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.

TL;DR: Recent developments with InterPro (version 70.0) and its associated software are reported, including an 18% growth in the size of the database in terms on new InterPro entries, updates to content, the inclusion of an additional entry type, refined modelling of discontinuous domains, and the development of a new programmatic interface and website.

TL;DR: Comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use finds that 86% of bacteria in this data set have at least one of 15 cobamide-dependent enzyme families, but only 37% are predicted to synthesize cobamides de novo.

TL;DR: Comparative genomics of 11,000 bacterial species is used to analyze the extent and distribution of cobamide production and use across bacteria, finding that 86% of bacteria in this data set have at least one of 15 cobamide-dependent enzyme families, yet only 37% are predicted to synthesize cobamides de novo.

TL;DR: To increase the scope of coverage, GPs have migrated to function as a companion resource utilizing InterPro entries, adding ∼700 new GPs, increasing the coverage of eukaryotic systems, as well as increasing general coverage through automatic generation of GPs from related resources.