L
Lai-Su L. Yeh
Researcher at Georgetown University Medical Center
Publications - 25
Citations - 22530
Lai-Su L. Yeh is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Sequence database & Protein structure database. The author has an hindex of 18, co-authored 25 publications receiving 17597 citations. Previous affiliations of Lai-Su L. Yeh include Georgetown University.
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Journal ArticleDOI
UniProt: the Universal Protein knowledgebase
Rolf Apweiler,Amos Marc Bairoch,Cathy H. Wu,Winona C. Barker,Brigitte Boeckmann,Serenella Ferro,Elisabeth Gasteiger,Hongzhan Huang,Rodrigo Lopez,Michele Magrane,Maria Jesus Martin,Darren A. Natale,Claire O'Donovan,Nicole Redaschi,Lai-Su L. Yeh +14 more
TL;DR: The Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt), which is to provide a comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and query interfaces.
Journal ArticleDOI
The Universal Protein Resource (UniProt)
Amos Marc Bairoch,Rolf Apweiler,Cathy H. Wu,Winona C. Barker,Brigitte Boeckmann,Serenella Ferro,Elisabeth Gasteiger,Hongzhan Huang,Rodrigo Lopez,Michele Magrane,Maria Jesus Martin,Darren A. Natale,Claire O'Donovan,Nicole Redaschi,Lai-Su L. Yeh +14 more
TL;DR: During 2004, tens of thousands of Knowledgebase records got manually annotated or updated; the UniProt keyword list got augmented by additional keywords; the documentation of the keywords and are continuously overhauling and standardizing the annotation of post-translational modifications.
Journal ArticleDOI
UniProt: A hub for protein information
Alex Bateman,Maria Jesus Martin,Claire O'Donovan,Michele Magrane,Rolf Apweiler,Emanuele Alpi,Ricardo Antunes,Joanna Arganiska,Benoit Bely,Mark Bingley,Carlos Bonilla,Ramona Britto,Borisas Bursteinas,Gayatri Chavali,Elena Cibrian-Uhalte,Alan Wilter Sousa da Silva,Maurizio De Giorgi,Tunca Doğan,Francesco Fazzini,Paul Gane,Leyla Jael Garcia Castro,Penelope Garmiri,Emma Hatton-Ellis,Reija Hieta,Rachael P. Huntley,Duncan Legge,W Liu,Jie Luo,Alistair MacDougall,Prudence Mutowo,Andrew Nightingale,Sandra Orchard,Klemens Pichler,Diego Poggioli,Sangya Pundir,Luis Pureza,Guoying Qi,Steven Rosanoff,Rabie Saidi,Tony Sawford,Aleksandra Shypitsyna,Edward Turner,Vladimir Volynkin,Tony Wardell,Xavier Watkins,Hermann Zellner,Andrew Peter Cowley,Luis Figueira,Weizhong Li,Hamish McWilliam,Rodrigo Lopez,Ioannis Xenarios,Lydie Bougueleret,Alan Bridge,Sylvain Poux,Nicole Redaschi,Lucila Aimo,Ghislaine Argoud-Puy,Andrea H. Auchincloss,Kristian B. Axelsen,Parit Bansal,Delphine Baratin,Marie Claude Blatter,Brigitte Boeckmann,Jerven Bolleman,Emmanuel Boutet,Lionel Breuza,Cristina Casal-Casas,Edouard de Castro,Elisabeth Coudert,Béatrice A. Cuche,M Doche,Dolnide Dornevil,Séverine Duvaud,Anne Estreicher,L Famiglietti,Marc Feuermann,Elisabeth Gasteiger,Sebastien Gehant,Vivienne Baillie Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,Florence Jungo,Guillaume Keller,Vicente Lara,P Lemercier,Damien Lieberherr,Thierry Lombardot,Xavier D. Martin,Patrick Masson,Anne Morgat,Teresa Batista Neto,Nevila Nouspikel,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Monica Pozzato,Manuela Pruess,Catherine Rivoire,Bernd Roechert,Michel Schneider,Christian J. A. Sigrist,K Sonesson,S Staehli,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,Anne Lise Veuthey,Cathy H. Wu,Cecilia N. Arighi,Leslie Arminski,Chuming Chen,Yongxing Chen,John S. Garavelli,Hongzhan Huang,Kati Laiho,Peter B. McGarvey,Darren A. Natale,Baris E. Suzek,C. R. Vinayaka,Qinghua Wang,Yuqi Wang,Lai-Su L. Yeh,Meher Shruti Yerramalla,Jian Zhang +127 more
TL;DR: An annotation score for all entries in UniProt is introduced to represent the relative amount of knowledge known about each protein to help identify which proteins are the best characterized and most informative for comparative analysis.
Journal ArticleDOI
UniProt: the universal protein knowledgebase in 2021
Alex Bateman,Maria Jesus Martin,Sandra Orchard,Michele Magrane,Rahat Agivetova,Shadab Ahmad,Emanuele Alpi,Emily H Bowler-Barnett,Ramona Britto,Borisas Bursteinas,Hema Bye-A-Jee,Ray Coetzee,Austra Cukura,Alan Wilter Sousa da Silva,Paul Denny,Tunca Doğan,ThankGod Ebenezer,Jun Fan,Leyla Jael Garcia Castro,Penelope Garmiri,George Georghiou,Leonardo Gonzales,Emma Hatton-Ellis,Abdulrahman Hussein,Alexandr Ignatchenko,Giuseppe Insana,Rizwan Ishtiaq,Petteri Jokinen,Vishal Joshi,Dushyanth Jyothi,Antonia Lock,Rodrigo Lopez,Aurelien Luciani,Jie Luo,Yvonne Lussi,Alistair MacDougall,Fábio Madeira,Mahdi Mahmoudy,Manuela Menchi,Alok Mishra,Katie Moulang,Andrew Nightingale,Carla Susana Oliveira,Sangya Pundir,Guoying Qi,Shriya Raj,Daniel Rice,Milagros Rodriguez Lopez,Rabie Saidi,Joseph Sampson,Tony Sawford,Elena Speretta,Edward Turner,Nidhi Tyagi,Preethi Vasudev,Vladimir Volynkin,Kate Warner,Xavier Watkins,Rossana Zaru,Hermann Zellner,Alan Bridge,Sylvain Poux,Nicole Redaschi,Lucila Aimo,Ghislaine Argoud-Puy,Andrea H. Auchincloss,Kristian B. Axelsen,Parit Bansal,Delphine Baratin,Marie-Claude Blatter,Jerven Bolleman,Emmanuel Boutet,Lionel Breuza,Cristina Casals-Casas,Edouard de Castro,Kamal Chikh Echioukh,Elisabeth Coudert,Béatrice A. Cuche,M Doche,Dolnide Dornevil,Anne Estreicher,Maria Livia Famiglietti,Marc Feuermann,Elisabeth Gasteiger,Sebastien Gehant,Vivienne Baillie Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,Nevila Hyka-Nouspikel,Florence Jungo,Guillaume Keller,Arnaud Kerhornou,Vicente Lara,Philippe Le Mercier,Damien Lieberherr,Thierry Lombardot,Xavier D. Martin,Patrick Masson,Anne Morgat,Teresa Batista Neto,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Lucille Pourcel,Monica Pozzato,Manuela Pruess,Catherine Rivoire,Christian J. A. Sigrist,K Sonesson,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,Cathy H. Wu,Cecilia N. Arighi,Leslie Arminski,Chuming Chen,Yongxing Chen,John S. Garavelli,Hongzhan Huang,Kati Laiho,Peter B. McGarvey,Darren A. Natale,Karen E. Ross,C. R. Vinayaka,Qinghua Wang,Yuqi Wang,Lai-Su L. Yeh,Jian Zhang,Patrick Ruch,Douglas Teodoro +132 more
TL;DR: The UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal and a credit-based publication submission interface was developed.
Journal ArticleDOI
InterPro in 2017-beyond protein family and domain annotations
Robert D. Finn,Teresa K. Attwood,Patricia C. Babbitt,Alex Bateman,Peer Bork,Alan Bridge,Hsin-Yu Chang,Zsuzsanna Dosztányi,Sara El-Gebali,Matthew Fraser,Julian Gough,David R. Haft,Gemma L. Holliday,Hongzhan Huang,Xiaosong Huang,Ivica Letunic,Rodrigo Lopez,Shennan Lu,Aron Marchler-Bauer,Huaiyu Mi,Jaina Mistry,Darren A. Natale,Marco Necci,Gift Nuka,Christine A. Orengo,Youngmi Park,Sebastien Pesseat,Damiano Piovesan,Simon C. Potter,Neil D. Rawlings,Nicole Redaschi,Lorna Richardson,Catherine Rivoire,Amaia Sangrador-Vegas,Christian J. A. Sigrist,Ian Sillitoe,Ben Smithers,Silvano Squizzato,Granger G. Sutton,Narmada Thanki,Paul Thomas,Silvio C. E. Tosatto,Cathy H. Wu,Ioannis Xenarios,Lai-Su L. Yeh,Siew Yit Young,Alex L. Mitchell +46 more
TL;DR: Recent developments with InterPro are reported, including the addition of two new databases, and the functionality to include residue-level annotation and prediction of intrinsic disorder, which enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.