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David S. Bredt
Researcher at Johnson & Johnson
Publications - 224
Citations - 63974
David S. Bredt is an academic researcher from Johnson & Johnson. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 107, co-authored 223 publications receiving 62332 citations. Previous affiliations of David S. Bredt include Johns Hopkins University & Georgetown University Medical Center.
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Journal ArticleDOI
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer.
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme (endothelium-derived relaxing factor/arginine/cGMP)
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: In this paper, it was shown that NO synthetase is a calmodulin-requiring enzyme, and showed that NO formation is accompanied by the stoichiometric conversion of arginine to citrulline.
Journal ArticleDOI
Localization of nitric oxide synthase indicating a neural role for nitric oxide
TL;DR: It is demonstrated that NO synthase in the brain to be exclusively associated with discrete neuronal populations, and prominent neural localizations provided the first conclusive evidence for a strong association of NO with neurons.
Journal ArticleDOI
Nitric oxide: a physiologic messenger molecule.
David S. Bredt,Solomon H. Snyder +1 more
Journal ArticleDOI
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.