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David S. Hersh
Researcher at University of Tennessee Health Science Center
Publications - 76
Citations - 2439
David S. Hersh is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 49 publications receiving 2041 citations. Previous affiliations of David S. Hersh include New York University & Boston Children's Hospital.
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Journal ArticleDOI
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
TL;DR: The data demonstrate that SipB functions as an analog of the Shigella invasin IpaB, and functional inhibition of caspase-1 activity by acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone blocks macrophage cytotoxicity, and macrophages lacking casp enzyme are not susceptible to Salmonella-induced apoptosis.
Journal ArticleDOI
Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB
Hubert Hilbi,Jeremy E. Moss,David S. Hersh,Yajing Chen,Josette Arondel,Subhashis Banerjee,Richard A. Flavell,Junying Yuan,Philippe J. Sansonetti,Arturo Zychlinsky +9 more
TL;DR: Data indicate that Shigella-induced apoptosis is distinct from other forms of apoptosis and seems uniquely dependent on Casp-1.
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Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model
Denise M. Monack,David S. Hersh,Nafisa Ghori,Donna M. Bouley,Arturo Zychlinsky,Stanley Falkow +5 more
TL;DR: The results show that Casp-1, which is both proapoptotic and proinflammatory, is essential for S. typhimurium to efficiently colonize the cecum and PP and subsequently cause systemic typhoid-like disease in mice.
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Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier.
David S. Hersh,Aniket S. Wadajkar,Nathan B. Roberts,Jimena G. Perez,Nina P. Connolly,Victor Frenkel,Jeffrey A. Winkles,Graeme F. Woodworth,Anthony J. Kim +8 more
TL;DR: The physiological properties of the blood-brain barrier, conventional strategies to enhance paracellular and transcellular transport through the BBB, emerging concepts to overcome theBBB, and alternative CNS drug delivery strategies that bypass the BBb entirely are discussed.
Journal ArticleDOI
Intramedullary Lesion Length on Postoperative Magnetic Resonance Imaging is a Strong Predictor of ASIA Impairment Scale Grade Conversion Following Decompressive Surgery in Cervical Spinal Cord Injury.
Bizhan Aarabi,Charles A. Sansur,David Ibrahimi,J M Simard,David S. Hersh,Elizabeth Le,Cara Diaz,Jennifer Massetti,Noori Akhtar-Danesh +8 more
TL;DR: Compared with other surrogates, IMLL remained as the only predictor of AIS grade conversion and stepwise multiple logistic regression analysis indicated IMLL was the sole and strongest indicator of Ais grade conversion.