D
David W. Scott
Researcher at University of British Columbia
Publications - 95
Citations - 7777
David W. Scott is an academic researcher from University of British Columbia. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Follicular lymphoma. The author has an hindex of 35, co-authored 95 publications receiving 6318 citations. Previous affiliations of David W. Scott include BC Cancer Agency & BC Cancer Research Centre.
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Journal ArticleDOI
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Ryan D. Morin,Maria Mendez-Lago,Andrew J. Mungall,Rodrigo Goya,Karen Mungall,Richard Corbett,Nathalie A. Johnson,Tesa M. Severson,Readman Chiu,Matthew A. Field,Shaun D. Jackman,Martin Krzywinski,David W. Scott,Diane L. Trinh,Jessica Tamura-Wells,Sa Li,Marlo Firme,Sanja Rogic,Malachi Griffith,Susanna Chan,Oleksandr Yakovenko,Irmtraud M. Meyer,Eric Y. Zhao,Duane E. Smailus,Michelle Moksa,Suganthi Chittaranjan,Lisa M. Rimsza,Angela Brooks-Wilson,Angela Brooks-Wilson,John J. Spinelli,Susana Ben-Neriah,Barbara Meissner,Bruce Woolcock,Merrill Boyle,Helen McDonald,Angela Tam,Yongjun Zhao,Allen Delaney,Thomas Zeng,Kane Tse,Yaron S.N. Butterfield,Inanc Birol,Robert A. Holt,Jacqueline E. Schein,Douglas E. Horsman,Richard A. Moore,Steven J.M. Jones,Joseph M. Connors,Martin Hirst,Randy D. Gascoyne,Marco A. Marra +50 more
TL;DR: Genes with roles in histone modification were frequent targets of somatic mutation and suggest a previously unappreciated disruption of chromatin biology in lymphomagenesis in NHLs.
Journal ArticleDOI
Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Nathalie A. Johnson,Graham W. Slack,Kerry J. Savage,Joseph M. Connors,Susana Ben-Neriah,Sanja Rogic,David W. Scott,King Tan,Christian Steidl,Laurie H. Sehn,Wing C. Chan,Javeed Iqbal,Paul N. Meyer,Georg Lenz,George E. Wright,Lisa M. Rimsza,Carlo Valentino,Patrick Brunhoeber,Thomas M. Grogan,Rita M. Braziel,James R. Cook,Raymond R. Tubbs,Dennis D. Weisenburger,Elias Campo,Andreas Rosenwald,German Ott,German Ott,Jan Delabie,Christina Holcroft,Elaine S. Jaffe,Louis M. Staudt,Randy D. Gascoyne +31 more
TL;DR: Assessment of MYC and BCL2 expression by IHC represents a robust, rapid, and inexpensive approach to risk-stratify patients with DLBCL at diagnosis.
Journal ArticleDOI
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin embedded tissue
David W. Scott,George E. Wright,P. Mickey Williams,Chih Jian Lih,William D. Walsh,Elaine S. Jaffe,Andreas Rosenwald,Elias Campo,Wing C. Chan,Joseph M. Connors,Erlend B. Smeland,Anja Mottok,Rita M. Braziel,German Ott,Jan Delabie,Raymond R. Tubbs,James R. Cook,Dennis D. Weisenburger,Timothy C. Greiner,Betty Glinsmann-Gibson,Kai Fu,Louis M. Staudt,Randy D. Gascoyne,Lisa M. Rimsza +23 more
TL;DR: The Lymphoma/Leukemia Molecular Profiling Project's Lymph2Cx assay is a parsimonious digital gene expression (NanoString)-based test for COO assignment in formalin-fixed paraffin-embedded tissue (FFPET) that is accurate, robust, and robust, with >95% concordance of COO assignments between 2 independent laboratories.
Journal ArticleDOI
The tumour microenvironment in B cell lymphomas
David W. Scott,Randy D. Gascoyne +1 more
TL;DR: A fundamental understanding of interactions between tumour cells and non-malignant cells gives insight into the pathogenesis of most B cell lymphomas and identifies novel therapeutic opportunities for targeting oncogenic pathways, both now and in the future.
Journal ArticleDOI
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.
Ryan D. Morin,Ryan D. Morin,Karen Mungall,Erin Pleasance,Andrew J. Mungall,Rodrigo Goya,Ryan D. Huff,David W. Scott,Jiarui Ding,Andrew Roth,Readman Chiu,Richard Corbett,Fong Chun Chan,Maria Mendez-Lago,Diane L. Trinh,Diane L. Trinh,Madison Bolger-Munro,Greg Taylor,Alireza Hadj Khodabakhshi,Susana Ben-Neriah,Julia R. Pon,Barbara Meissner,Bruce Woolcock,Noushin Farnoud,Sanja Rogic,Emilia L. Lim,Nathalie A. Johnson,Sohrab P. Shah,Steven J.M. Jones,Steven J.M. Jones,Christian Steidl,Christian Steidl,Robert A. Holt,Robert A. Holt,Inanc Birol,Inanc Birol,Richard A. Moore,Joseph M. Connors,Randy D. Gascoyne,Randy D. Gascoyne,Marco A. Marra,Marco A. Marra +41 more
TL;DR: A whole-genome-sequencing-based perspective ofDLBCL mutational complexity is provided by characterizing 40 de novo DLBCL cases and 13 cell lines and combining these data with DNA copy number analysis and RNA-seq from an extended cohort of 96 cases, which uncovered new gene targets of recurrent somatic point mutations and genes that are targeted by focal somatic deletions in this disease.