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Irmtraud M. Meyer
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 52
Citations - 5481
Irmtraud M. Meyer is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: RNA & Nucleic acid secondary structure. The author has an hindex of 23, co-authored 48 publications receiving 4891 citations. Previous affiliations of Irmtraud M. Meyer include University of Oxford & University of British Columbia.
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Journal ArticleDOI
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah,Andrew Roth,Rodrigo Goya,Arusha Oloumi,Gavin Ha,Yongjun Zhao,Gulisa Turashvili,Jiarui Ding,Kane Tse,Gholamreza Haffari,Ali Bashashati,Leah M Prentice,Jaswinder Khattra,Angela Burleigh,Damian Yap,Virginie Bernard,Andrew McPherson,Karey Shumansky,Anamaria Crisan,Ryan Giuliany,Alireza Heravi-Moussavi,Jamie Rosner,Daniel Lai,Inanc Birol,Richard Varhol,Angela Tam,Noreen Dhalla,Thomas Zeng,Kevin C. Ma,Simon K. Chan,Malachi Griffith,Annie Moradian,S.-W. Grace Cheng,Gregg B. Morin,Peter H. Watson,Karen A. Gelmon,Stephen Chia,Suet-Feung Chin,Christina Curtis,Christina Curtis,Oscar M. Rueda,Paul D.P. Pharoah,Sambasivarao Damaraju,John R. Mackey,Kelly Hoon,Timothy T. Harkins,Vasisht Tadigotla,Mahvash Sigaroudinia,Philippe Gascard,Thea D. Tlsty,Joseph F. Costello,Irmtraud M. Meyer,Connie J. Eaves,Wyeth W. Wasserman,Steven J.M. Jones,Steven J.M. Jones,David G. Huntsman,David G. Huntsman,Martin Hirst,Carlos Caldas,Marco A. Marra,Samuel Aparicio +61 more
TL;DR: It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes, and for the first time in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population is determined.
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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Ryan D. Morin,Maria Mendez-Lago,Andrew J. Mungall,Rodrigo Goya,Karen Mungall,Richard Corbett,Nathalie A. Johnson,Tesa M. Severson,Readman Chiu,Matthew A. Field,Shaun D. Jackman,Martin Krzywinski,David W. Scott,Diane L. Trinh,Jessica Tamura-Wells,Sa Li,Marlo Firme,Sanja Rogic,Malachi Griffith,Susanna Chan,Oleksandr Yakovenko,Irmtraud M. Meyer,Eric Y. Zhao,Duane E. Smailus,Michelle Moksa,Suganthi Chittaranjan,Lisa M. Rimsza,Angela Brooks-Wilson,Angela Brooks-Wilson,John J. Spinelli,Susana Ben-Neriah,Barbara Meissner,Bruce Woolcock,Merrill Boyle,Helen McDonald,Angela Tam,Yongjun Zhao,Allen Delaney,Thomas Zeng,Kane Tse,Yaron S.N. Butterfield,Inanc Birol,Robert A. Holt,Jacqueline E. Schein,Douglas E. Horsman,Richard A. Moore,Steven J.M. Jones,Joseph M. Connors,Martin Hirst,Randy D. Gascoyne,Marco A. Marra +50 more
TL;DR: Genes with roles in histone modification were frequent targets of somatic mutation and suggest a previously unappreciated disruption of chromatin biology in lymphomagenesis in NHLs.
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The genome of the simian and human malaria parasite Plasmodium knowlesi
Arnab Pain,Ulrike Böhme,Andrew Berry,Karen Mungall,Robert D. Finn,Andrew P. Jackson,Tobias Mourier,Jaina Mistry,Erica M. Pasini,Martin Aslett,S. Balasubrammaniam,Karsten M. Borgwardt,Karen Brooks,Celine Carret,Tim Carver,Inna Cherevach,Tracey Chillingworth,Taane G. Clark,Taane G. Clark,Mary R. Galinski,Neil Hall,D. Harper,David Harris,Heidi Hauser,Al Ivens,Christoph S. Janssen,Thomas M. Keane,Natasha Larke,Stacey A. Lapp,Matthias Marti,Sharon Moule,Irmtraud M. Meyer,Douglas Ormond,Nicholas S. Peters,Mandy Sanders,S. Sanders,Tobias Sargeant,Tobias Sargeant,Mark Simmonds,Frances Smith,R. Squares,Scott Thurston,Adrian Tivey,Danielle Walker,Brian White,Eduard Zuiderwijk,Carol Churcher,Michael A. Quail,Alan F. Cowman,C. M. R. Turner,Marie-Adèle Rajandream,Clemens H. M. Kocken,Alan W. Thomas,Chris I. Newbold,Chris I. Newbold,Bart Barrell,Matthew Berriman +56 more
TL;DR: This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes.
Journal ArticleDOI
Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis
TL;DR: An interlocked feedback loop is identified through which two RNA-binding proteins autoregulate and reciprocally crossregulate by coupling unproductive splicing to NMD, pointing to a high degree of evolutionary sequence conservation in the introns retained in as_AtGRP8 or as_ atGRP7.
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On the importance of cotranscriptional RNA structure formation.
TL;DR: The existing evidence for cotranscriptional folding is summarized, the different, currently used strategies for RNA secondary-structure prediction are reviewed and a range of ideas on how state-of-the-art methods could be potentially improved by explicitly capturing the process of cotrancriptional structure formation are proposed.