Sanja Rogic

TL;DR: Genes with roles in histone modification were frequent targets of somatic mutation and suggest a previously unappreciated disruption of chromatin biology in lymphomagenesis in NHLs.

TL;DR: The construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions are reported.

TL;DR: Assessment of MYC and BCL2 expression by IHC represents a robust, rapid, and inexpensive approach to risk-stratify patients with DLBCL at diagnosis.

TL;DR: A whole-genome-sequencing-based perspective ofDLBCL mutational complexity is provided by characterizing 40 de novo DLBCL cases and 13 cell lines and combining these data with DNA copy number analysis and RNA-seq from an extended cohort of 96 cases, which uncovered new gene targets of recurrent somatic point mutations and genes that are targeted by focal somatic deletions in this disease.

TL;DR: Recurrent NOTCH1 mutations are identified that provide the preclinical rationale for therapeutic inhibition of the NOTCH pathway in a subset of patients with MCL and are shown to reduce proliferation and induced apoptosis in 2 MCL cell lines.