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William D. Walsh
Researcher at Leidos
Publications - 8
Citations - 800
William D. Walsh is an academic researcher from Leidos. The author has contributed to research in topics: Cancer & Diffuse large B-cell lymphoma. The author has an hindex of 6, co-authored 8 publications receiving 671 citations.
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Journal ArticleDOI
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin embedded tissue
David W. Scott,George E. Wright,P. Mickey Williams,Chih Jian Lih,William D. Walsh,Elaine S. Jaffe,Andreas Rosenwald,Elias Campo,Wing C. Chan,Joseph M. Connors,Erlend B. Smeland,Anja Mottok,Rita M. Braziel,German Ott,Jan Delabie,Raymond R. Tubbs,James R. Cook,Dennis D. Weisenburger,Timothy C. Greiner,Betty Glinsmann-Gibson,Kai Fu,Louis M. Staudt,Randy D. Gascoyne,Lisa M. Rimsza +23 more
TL;DR: The Lymphoma/Leukemia Molecular Profiling Project's Lymph2Cx assay is a parsimonious digital gene expression (NanoString)-based test for COO assignment in formalin-fixed paraffin-embedded tissue (FFPET) that is accurate, robust, and robust, with >95% concordance of COO assignments between 2 independent laboratories.
Journal ArticleDOI
Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer
Shivaani Kummar,Amit M. Oza,Gini F. Fleming,Daniel M. Sullivan,David R. Gandara,Michael Naughton,Miguel A. Villalona-Calero,Robert J. Morgan,Peter M. Szabó,Ahrim Youn,Alice P. Chen,Jiuping Ji,Deborah Allen,Chih Jian Lih,Michele G. Mehaffey,William D. Walsh,Paul M. McGregor,Seth M. Steinberg,P. Mickey Williams,Robert J. Kinders,Barbara A. Conley,Richard M. Simon,James H. Doroshow +22 more
TL;DR: This is the first trial that evaluated single-agent, low-dose cyclophosphamide in HGSOC, peritoneal, fallopian tube, and BRCA-mutant ovarian cancers and it was well tolerated and clinical activity was observed.
Journal ArticleDOI
Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue
Danielle M. Carrick,Michele G. Mehaffey,Michael C. Sachs,Sean F. Altekruse,Corinne Camalier,Rodrigo F. Chuaqui,Wendy Cozen,Biswajit Das,Brenda Y. Hernandez,Chih-Jian Lih,Charles F. Lynch,Hala R. Makhlouf,Paul M. McGregor,Lisa M. McShane,JoyAnn Phillips Rohan,William D. Walsh,Paul M. Williams,Elizabeth M. Gillanders,Leah E. Mechanic,Sheri D. Schully +19 more
TL;DR: This feasibility study demonstrates FFPE specimens acquired from SEER registries after varying lengths of storage time and under varying storage conditions are a promising source of DNA for NGS.
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Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial
Chih Jian Lih,David J. Sims,Robin D. Harrington,Eric C. Polley,Yingdong Zhao,Michele G. Mehaffey,Thomas Forbes,Biswajit Das,William D. Walsh,Vivekananda Datta,Kneshay N. Harper,Courtney H. Bouk,Larry Rubinstein,Richard M. Simon,Barbara A. Conley,Alice P. Chen,Shivaani Kummar,James H. Doroshow,Paul M. Williams +18 more
TL;DR: The NCI-MPACT assay is well suited for its intended investigational use and can serve as a template for developing next-generation sequencing assays for other cancer clinical trial applications.
Journal ArticleDOI
A mutational comparison of adult and adolescent and young adult (AYA) colon cancer.
James V. Tricoli,Lisa A. Boardman,Rajesh Patidar,Sivasish Sindiri,Jin S. Jang,William D. Walsh,Paul M. McGregor,Corinne Camalier,Michele G. Mehaffey,Wayne L. Furman,Armita Bahrami,P. Mickey Williams,Chih Jian Lih,Barbara A. Conley,Javed Khan +14 more
TL;DR: It is possible that the relative lack of progress in treatment outcomes among adolescent and young adult (AYA) patients with cancer is caused by a difference in disease biology compared with the corresponding diseases in younger and older individuals.